Regulation of Histone Deacetylase 6 Activity via S-Nitrosylation

Biological & Pharmaceutical Bulletin
Kosaku OkudaTakashi Uehara

Abstract

Nitric oxide (NO) is a gaseous regulatory factor produced by NO synthases (NOS) and it plays several critical roles via S-nitrosylation of protein cysteine residues. Histone deacetylase (HDAC) functions in the maintenance/balance of chromatin acetylation and contributes to transcriptional supression. It has been reported that S-nitrosylation of HDAC2 is involved in the regulation of deacetylase activity. However, it remains unknown whether other subtypes of the HDAC family are S-nitrosylated. In the present study, we found that HDAC6 is a target of NO. A biotin-switch assay revealed that endogenous HDAC6 is S-nitrosylated by both NO donors and NO derived from the inducible type of NOS in cells treated with cytokines. NO led to suppressed deacetylase activity in vitro and increased acetylated α-tubulin, a major substrate for HDAC6, in A549 cells. These findings suggest that S-nitrosylation of HDAC6 plays a pivotal role in the regulation of protein acetylation.

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Citations

Feb 26, 2016·ACS Chemical Biology·Jeffrey E LópezCarol A Fierke
Sep 1, 2016·Oxidative Medicine and Cellular Longevity·Jan NevoralJaroslav Petr
May 20, 2017·Neurochemical Research·Yoshiki Koriyama, Ayako Furukawa
Jul 22, 2019·Journal of Experimental Botany·Inmaculada Sánchez-VicenteOscar Lorenzo
Oct 23, 2019·Frontiers in Plant Science·Yongfeng HuDao-Xiu Zhou
Jun 14, 2019·Frontiers in Plant Science·Alexandra Ageeva-KieferleChristian Lindermayr
Jun 4, 2019·Biological & Pharmaceutical Bulletin·Kengo NakaharaTakashi Uehara
Jan 23, 2021·Free Radical Biology & Medicine·Hannah Petraitis KuschmanDouglas D Thomas
Nov 1, 2020·Journal of Experimental Botany·Christoph J Wurm, Christian Lindermayr
Apr 4, 2021·Antioxidants·Lucie Valek, Irmgard Tegeder
May 19, 2021·Plant Physiology·Alexandra Ageeva-KieferleChristian Lindermayr
Jul 3, 2021·International Journal of Molecular Sciences·Patricia de la Cruz-OjedaJordi Muntané

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