PMID: 11322887Apr 27, 2001Paper

Regulation of human and mouse procathepsin E gene expression

European Journal of Biochemistry
M CookP Tatnell

Abstract

Cathepsin E is an intracellular aspartic proteinase that is considered to have a number of physiological roles including antigen processing. Quantitation of procathepsin E mRNA by LightCyclertrade mark technology indicated that the gene was transcribed in lung but not in kidney of both human and mouse origin. In contrast, the transcript was present in mouse spleen and alveolar macrophages but not in the counterpart tissue/cells from humans. Regulation of human and mouse procathepsin E gene expression was shown not to be influenced by the extent of CpG methylation but depended on the recognition of potential binding motifs in each promoter region by transcription factors such as GATA1, PU1 and YY1, as revealed by functional analysis using a series of promoter/luciferase reporter gene fusion constructs. Thus the extent to which the procathepsin E gene is expressed in a particular cell type may depend on the balance between the effects produced by positive-acting, cell-specific transcription factors such as GATA1 and PU1 and the negative influence of the ubiquitous YY1 factor. In this way, the relative abundance and influence of general and cell-specific transcription factors can govern the production of cathepsin E and thereby ac...Continue Reading

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Citations

Nov 15, 2007·Immunogenetics·Calogero TuloneBenny Chain
Mar 4, 2014·Biochemical and Biophysical Research Communications·Tomoko KadowakiKenji Yamamoto
Dec 13, 2005·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lizette BusquetsMary Prorok
Dec 3, 2011·Journal of Biochemistry·Kuniaki OkamotoKenji Yamamoto
Oct 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroe KakehashiKenji Yamamoto
Dec 21, 2019·Virchows Archiv : an International Journal of Pathology·Fabian FaklerHelmut Popper
Jul 1, 2004·The Biochemical Journal·Dawn C-I KohK Jeyaseelan
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ying WangManuela Cernadas
Apr 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christina S K YeeCheong-Hee Chang
Jan 18, 2003·Biochimica Et Biophysica Acta·Peter J TatnellJohn Kay
Sep 25, 2007·Archives of Biochemistry and Biophysics·Jeanine L PageCurtis J Omiecinski
Jan 8, 2008·Biochemical and Biophysical Research Communications·Nousheen Zaidi, Hubert Kalbacher

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