Regulation of human cytosolic sulfotransferases 1C2 and 1C3 by nuclear signaling pathways in LS180 colorectal adenocarcinoma cells.

Drug Metabolism and Disposition : the Biological Fate of Chemicals
Elizabeth A RondiniThomas A Kocarek

Abstract

Cytosolic sulfotransferases (SULTs) catalyze the sulfate conjugation of a myriad of endogenous and xenobiotic substrates. Among the 13 human SULTs, little is known regarding regulation of the SULT1C subfamily. We evaluated the effects of a panel of transcription factor activators on levels of SULT1C mRNA (1C2 and 1C3) and protein (1C2) in LS180 colorectal adenocarcinoma cells. Treatment with 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride [GW3965, liver X receptor (LXR) activator], 3-(2,6-dichlorophenyl)-4-(3'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole [GW4064, farnesoid X receptor (FXR)], or rifampicin [pregnane X receptor (PXR)] moderately (≤2-fold) increased both SULT1C2 and SULT1C3 mRNA levels. 1α,25-Dihydroxyvitamin D3 [1,25(OH)2D3, vitamin D receptor (VDR)] selectively upregulated SULT1C2, whereas ciprofibrate [peroxisome proliferator-activated receptor α (PPARα)], rosiglitazone (PPARγ), and 2,3,7,8-tetrachlorodibenzo-p-dioxin [aryl hydrocarbon receptor (AhR)] selectively increased SULT1C3 mRNA levels. SULT1C2 protein content was strongly increased by 1,25(OH)2D3 treatment and moderately increased by GW3965, GW4064, and rifampicin. To evaluate ...Continue Reading

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Citations

Apr 25, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Tatiana Claro da SilvaGerd A Kullak-Ublick
May 14, 2016·Chemico-biological Interactions·Michael W H Coughtrie
May 1, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kathleen G BarrettMelissa Runge-Morris
Sep 21, 2017·The Journal of Pharmacology and Experimental Therapeutics·Elizabeth A RondiniJames G Granneman
Jun 3, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Sarah DubaisiMelissa Runge-Morris
Dec 18, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Zofia Duniec-DmuchowskiThomas A Kocarek
May 8, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kathleen G BarrettMelissa Runge-Morris
Oct 3, 2015·The Journal of Pharmacology and Experimental Therapeutics·Elizabeth A RondiniThomas A Kocarek
Apr 19, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Sarah DubaisiMelissa Runge-Morris

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