PMID: 9434795Jan 22, 1998Paper

Regulation of human cytotoxic T lymphocytes development by the synergistic effect of IL-7 and sCD23

Clinical Immunology and Immunopathology
C FratazziC Carini

Abstract

The present study was undertaken to investigate the interaction of IL-7 and sCD23 on human peripheral blood T cell activation and CTL differentiation. Purified T lymphocytes were stimulated with mitogen plus IL-2 and subcultured for 7 days with IL-7 and/or sCD23. The combination of IL-7 and sCD23 synergistically enhanced the proliferation of both CD4+ and CD8+. T cells. CD8+ T cells, however, were usually more responsive to IL-7 and sCD23. This synergy was observed on both subsets of T cells. Furthermore, these cytokines synergistically augment the CTL activity of CD8+ T cells in both mitogen- and antigen-activated T cells. MAbs anti-IL-2 or anti-IL-2R (CD25) and anti-IL-12 had no effect on T cell proliferation and CD8+ cytotoxic activity induced by IL-7 and sCD23. We analyzed the effect on IFN-gamma induction by CD8+ T cells and found that IL-7 alone was incapable of inducing detectable levels of IFN-gamma production, but together with sCD23 it enhanced the production of IFN-gamma. We also found that IFN-gamma was not required for enhanced CTL activity of CD8+ T cells, because rabbit anti-IFN-gamma did not block the synergistic effects of either cytokine. The data demonstrate that the synergistic stimulatory activity of IL-7 a...Continue Reading

References

Jan 1, 1989·European Journal of Immunology·R J ArmitageP C Beverley
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R G GoodwinA E Namen
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G D ChazenE M Shevach
Jan 1, 1988·The Journal of Experimental Medicine·J Y BonnefoyJ Banchereau
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C CariniK Ishizaka
Jan 1, 1993·Microbiology and Immunology·D HoberM Maniez-Montreuil
Apr 1, 1993·European Journal of Immunology·J Y BonnefoyJ Gordon
May 1, 1996·International Archives of Allergy and Immunology·C Carini, C Fratazzi

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