PMID: 8944639Nov 1, 1996Paper

Regulation of human erythrocyte Na+/H+ exchange by soluble and particulate guanylate cyclase

The American Journal of Physiology
V Petrov, P Lijnen

Abstract

Guanylate cyclase activity in human erythrocytes is investigated by evaluating the intracellular guanosine 3',5'-cyclic monophosphate (cGMP) content in the presence of various agents that exert specific effects on soluble or particulate guanylate cyclase. The increase in the intraerythrocyte cGMP content by the soluble guanylate cyclase activators nitroprusside and NaNO2 suggests the presence of this enzyme in human erythrocytes. The effects of four different atrial natriuretic peptide (ANP) fragments on the intraerythrocyte cGMP content is also studied. ANP II and ANP III increase the intraerythrocyte cGMP content, whereas ANP I and des-Ser5,des-Ser6-ANP III are ineffective. Thus our data show that human erythrocytes possess particulate guanylate cyclase together with the soluble enzyme. The ANP fragments ANP II and ANP III also activate the erythrocyte Na+/H+ exchange. Nitroprusside, M & B 22948 (an inhibitor of cGMP phosphodiesterase), and the cGMP analogues dibutyryl cGMP and 8-bromoguanosine 3',5'-cyclic monophosphate also increase the erythrocyte Na+/H+ exchange rate. The latter data also suggest that the erythrocyte Na+/H+ exchange is regulated by cGMP.

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Citations

Feb 9, 2000·American Journal of Physiology. Cell Physiology·N C AdragnaP K Lauf
Oct 26, 2005·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Cinzia FatiniRosanna Abbate
Feb 27, 2004·British Journal of Haematology·Nicola ConranFernando F Costa
Jan 25, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Nadezhda N BarvitenkoRoy E Weber
Mar 15, 2012·American Journal of Physiology. Endocrinology and Metabolism·Adelaide Del ViscovoLorella M T Canzoniero
Apr 13, 2011·Free Radical Research·Patrick HornPetra Kleinbongard
Jan 11, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Melek Bor-KucukatayOguz K Baskurt
Apr 29, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Shaquria P AdderleyRandy S Sprague
Dec 16, 2017·Journal of Cellular Physiology·Georg SagerOle-Martin Fuskevaag
Mar 30, 2005·Biochemical Pharmacology·Chung-Pu WuMargery A Barrand

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