PMID: 7539397Jun 1, 1995Paper

Regulation of human Gc (vitamin D--binding) protein levels: hormonal and cytokine control of gene expression in vitro

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
C GuhaG V Paddock

Abstract

Studies were performed in Hep3B hepatocytes to better elucidate the mechanisms regulating circulating levels of human group-specific component (Gc). We measured changes in Gc messenger RNA (mRNA) synthesis and levels of secreted protein resulting from treatment of hepatocytes with cytokines and hormones known to influence synthesis of other proteins of hepatic origin. We particularly focused on compounds known to be prototypic stimulants during the acute phase response. Interleukin-6 (IL-6) and dexamethasone were shown to increase Gc mRNA approximately twofold while transforming growth factor beta (TGF beta) decreased Gc mRNA in a dose-dependent fashion by up to fivefold. The effects on secreted Gc protein levels were similar. These results indicate that Gc protein appears to be regulated differently than the other members of this gene family, albumin and alpha-fetoprotein (AFP), which are negative acute phase reactants. In addition, these contrasting effects on Gc synthesis of IL-6 and dexamethasone and of TGF beta suggest that high basal levels of Gc synthesis may be maintained during the acute phase response.

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Citations

Jul 1, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·F V SchiodtP Ott
Feb 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D HunterT D Spector
Oct 15, 2013·PloS One·Stella LiongHarry M Georgiou
Jan 5, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·M T MuratoreA Ciapini
Apr 23, 2013·European Journal of Nutrition·Therese KarlssonIngrid Larsson
Nov 3, 2015·Best Practice & Research. Clinical Endocrinology & Metabolism·Joris R DelangheMarijn M Speeckaert
Oct 8, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Roger Bouillon, Dan Bikle

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