PMID: 2101871Jan 1, 1990Paper

Regulation of human megakaryocytopoiesis

Nouvelle Revue Française D'hématologie
Z C HanJ P Caen

Abstract

Megakaryocytopoiesis is a complex, highly regulated cellular and biologic process which leads to the production of platelets. The proliferation of megakaryocyte (MK) progenitors is mainly regulated by interleukin-3, granulocyte-macrophage colony-stimulating factor and an as yet uncharacterized MK colony-stimulating factor. The maturation of MKs to produce platelets is essentially regulated by interleukin-6 and thrombopoietin. Optimal megakaryocytopoiesis is controlled by appropriate combinations of positive and negative influence. Megakaryocytopoietic inhibition is controlled by transforming growth factor beta, platelet factor 4 and its related proteins, interferon-alpha and -gamma.

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E FibachP A Marks
Sep 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·T T Odell, C Shelton
Apr 1, 1985·The Journal of Clinical Investigation·R HoffmanJ E Straneva
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J W GoodmanS G Shinpock
Jul 1, 1985·Journal of Cellular Physiology·L A SolbergH A Messner
Mar 1, 1968·The Journal of Clinical Investigation·L A Harker
Jul 1, 1969·British Journal of Haematology·T T OdellD E Charsha
Jun 1, 1969·The Journal of Clinical Investigation·L A Harker, C A Finch
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Oct 1, 1983·Journal of Cellular Physiology·R K StuartC Caramatti
Nov 1, 1984·The Journal of Clinical Investigation·M W LongL A Boxer
Jul 1, 1981·The Journal of Experimental Medicine·E M RabellinoR L Nachman
Jan 1, 1982·Journal of Cellular Physiology. Supplement·H A MessnerC Izaguirre
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E FibachR A Rifkind
Oct 1, 1982·British Journal of Haematology·N Williams, R F Levine
Jan 1, 1982·Journal of Cellular Physiology·N WilliamsD J Nelson
Sep 1, 1981·The Journal of Clinical Investigation·E M MazurE Bruno

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Citations

Jul 1, 1990·International Journal of Cell Cloning·A M Gewirtz, B Calabretta
Jan 1, 1992·International Journal of Cell Cloning·Y YonemuraK Takatsuki
Mar 1, 1992·International Journal of Cell Cloning·H AvrahamJ E Groopman
Jul 1, 1992·International Journal of Cell Cloning·S A CowleyH Avraham
Jan 1, 1990·Molecular Aspects of Medicine·A Shock, G J Laurent
Jan 1, 1993·Cancer Genetics and Cytogenetics·Y L KwongL C Chan
Nov 1, 1995·Critical Reviews in Oncology/hematology·J E Trey, I Kushner
Aug 1, 1995·Critical Reviews in Oncology/hematology·W VainchenkerF Wendling
Nov 1, 1995·Critical Reviews in Oncology/hematology·G Zauli, L Catani
Jan 9, 2001·Experimental Hematology·G CavalloniM Aglietta
Aug 30, 2000·Early Human Development·N A MurrayI A Roberts
Mar 1, 1994·Baillière's Clinical Haematology·Z C Han, J P Caen
Feb 6, 1997·Transfusion Science·S Bolam
Feb 7, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S TornhamreJ A Lindgren
Oct 1, 1991·British Journal of Haematology·C W HollenS A Burstein
Sep 23, 2010·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Faris Q AlenziRichard K H Wyse
Oct 1, 1992·Leukemia & Lymphoma·C W HollenS A Burstein

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