Regulation of human renin secretion and gene transcription in Calu-6 cells

FEBS Letters
Stéphane GermainFlorence Pinet

Abstract

Calu-6 cells were characterized for studying the transcriptional regulation of the human renin gene. Analysis of cis-acting elements of the renin promoter showed the highest activity within the first 582 bp in serum-free conditions and of the 892 bp in the presence of serum. cAMP activates renin mRNA synthesis parallel to renin production (20-fold increase) as well renin promoter activity (2-fold). cAMP response element and the (-77 to -67) element are both necessary for activation of the renin promoter but do not act independently. Functional analysis of Intron A revealed the presence of a silencer specific to renin-producing cells.

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Citations

Mar 23, 2011·Pflügers Archiv : European journal of physiology·Michael DeschVladimir T Todorov
Jul 9, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tamás TerebessyIstván Mucsi
Jan 7, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M Bader
Jul 27, 1999·Journal of Hypertension·S GermainF Pinet
Feb 6, 2003·Journal of Hypertension·Sébastien FuchsFlorence Pinet
Sep 17, 1998·The Journal of Biological Chemistry·S GermainF Pinet
Dec 11, 2002·Journal of Hypertension·Sébastien FuchsFlorence Pinet
Oct 12, 1999·The American Journal of Physiology·J Wang, J C Rose
Sep 9, 2004·Molecular and Cellular Endocrinology·Kouichi TamuraVictor J Dzau

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