PMID: 18407091May 1, 1992Paper

Regulation of hypothalamic neuropeptide expression by peripheral metabolism

Trends in Endocrinology and Metabolism : TEM
M BerelowitzJ D White

Abstract

The mechanisms of appetite and body-weight regulation by peripheral signals are highly complex in vertebrates and remain poorly understood. It is intuitively apparent that such regulation must involve interactions between peripheral metabolic status and the brain, but what are the signals recognized by the brain to initiate feeding? The hypothalamus has long been recognized as central in "recognition" of peripheral nutrient and metabolic signals (and, perhaps, body weight status) and in "regulation" of hunger and satiety responses and, therefore, is a logical site on which to focus research aimed at understanding interactions between and regulation of the periphery and central nervous system. Recent studies demonstrating modulation of hypothalamic neurotransmitter expression by peripheral metabolic status may yield insights into regulation of appetite and metabolism in obesity and aberrant metabolic homeostasis. This review concentrates on summarizing data regarding regulation of expression of neuropeptide Y and growth hormone-releasing hormone as model peptide systems for addressing questions relating peripheral metabolism and hypothalamic neuropeptide expression.

References

Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S P KalraP S Kalra
Mar 1, 1988·Trends in Neurosciences·D G BaskinD M Dorsa
Jan 1, 1986·Annual Review of Physiology·M C Gelato, G R Merriam
Sep 1, 1988·The Journal of Clinical Investigation·M O Thorner, M L Vance
Sep 1, 1988·The Journal of Endocrinology·J M HollyJ A Wass
Aug 1, 1987·Endocrine Reviews·J E Morley
Aug 26, 1983·Science·Y S AllenJ M Polak
Aug 1, 1990·Molecular and Cellular Neurosciences·J D White, M Kershaw

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Citations

Aug 1, 1995·Pharmacology, Biochemistry, and Behavior·C M Brown, D V Coscina
Aug 1, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·B Beck
Sep 1, 1993·Trends in Endocrinology and Metabolism : TEM·A Sahu, S P Kalra
Feb 28, 2001·Diabetes, Obesity & Metabolism·B BaranowskaM Borowiec
Apr 19, 2002·The Journal of Pharmacology and Experimental Therapeutics·Chun-Su YuanHan H Aung
Apr 30, 1999·Physiological Reviews·E E MüllerD Cocchi

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