Regulation of hypothalamic somatostatin, growth hormone-releasing hormone, and growth hormone receptor messenger ribonucleic acid by glucocorticoids

Endocrinology
R SeñarisC Diéguez

Abstract

Although it is well known that chronic treatment with glucocorticoids inhibits somatic growth, the mechanism of action of this inhibitory effect is not completely understood. It is likely that glucocorticoids act at various levels, including pituitary, hypothalamus, and peripheral organs modulating GH synthesis, secretion, and action. In this work, we evaluated the effect of dexamethasone on hypothalamic somatostatin and GH-releasing hormone (GHRH) messenger RNA (mRNA) levels by in situ hybridization. We found a significant decrease of somatostatin mRNA content in the periventricular nucleus of the hypothalamus after 3, 8, and 15 days of treatment with dexamethasone. Furthermore, we observed a reduction in GHRH mRNA levels in the arcuate nucleus after 8 and 15 days of treatment with this steroid. As it has been shown that GH feeds back to regulate somatostatin and GHRH expression at the hypothalamic level through high affinity GH receptors, we evaluated the possibility of a GH-mediated action in the inhibitory effect of glucocorticoids on somatostatin and GHRH mRNA levels. To address this issue, we first studied the GH receptor mRNA content in both the periventricular and arcuate nuclei of the hypothalamus after dexamethasone t...Continue Reading

Citations

Mar 30, 1999·Brain Research. Molecular Brain Research·E CarroC Diéguez
Jun 14, 2005·Brain, Behavior, and Immunity·Jeremiah A AltJames M Krueger
Oct 24, 2002·Neuroreport·Miguel LópezCarlos Diéguez
Aug 7, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·R Nass, M O Thorner
Dec 22, 2010·Neuropharmacology·Antonia SerranoFernando Rodríguez de Fonseca
May 3, 2005·General and Comparative Endocrinology·Laura E Nelson, Mark A Sheridan
Nov 17, 2004·Regulatory Peptides·Teresa PriegoAsunción López-Calderón
Mar 19, 2015·The British Journal of Nutrition·Hassiba BenbaibecheElhadj Ahmed Koceïr
Jun 9, 2000·Journal of Neuroendocrinology·H TamuraI Wakabayashi
Oct 10, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Teresinha Lermen Donatti, Vera Hermina Koch
Oct 1, 2008·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Eunhee KimSeungjoon Park
Feb 6, 2013·Nature Reviews. Endocrinology·Gherardo Mazziotti, Andrea Giustina
Nov 24, 2006·American Journal of Physiology. Endocrinology and Metabolism·Raul M LuqueRhonda D Kineman
Sep 18, 2008·Arquivos brasileiros de endocrinologia e metabologia·Carlos Eduardo Martinelli, Heloísa M Cunha Palhares
Jan 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K R KritschD M Ney
Mar 11, 2004·Clinical Endocrinology·Marinella TzanelaNikos C Thalassinos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.