Regulation of hypoxia-inducible genes by PGC-1 alpha

Arteriosclerosis, Thrombosis, and Vascular Biology
Jonathan Shoag, Zolt Arany

Abstract

Atmospheric oxygen appeared approximately 2.3 billion years ago and sustains most complex life on earth. As mitochondria evolved to harness the energy in oxygen, systems developed to sense and respond to local oxygen concentrations and metabolic conditions. For more than a decade, research has focused on hypoxia-inducible factor 1 (HIF1), a key component of the eukaryotic oxygen-response system. Recently, evidence for other systems has also surfaced. One of these systems involves the PGC-1 alpha coactivator, a powerful transcriptional regulator of mitochondria and oxidative metabolic programs. This brief review will focus on this burgeoning role for PGC-1 alpha and will highlight the many questions that remain unanswered.

References

Aug 8, 1997·The Journal of Biological Chemistry·T YinJ Whelan
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·D KnuttiA Kralli
Dec 7, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Keith BaarJohn O Holloszy
Feb 8, 2003·Science·Enzo NisoliMichele O Carruba
Sep 16, 2003·Journal of Applied Physiology·Jessica NorrbomThomas Gustafsson
Aug 12, 2004·Physiology·Gregg L Semenza
Oct 14, 2004·Cell·Bruce M Spiegelman, Reinhart Heinrich
May 26, 2005·Cardiovascular Research·Inmaculada ValleMaría Monsalve
Jun 21, 2005·Genes & Development·Catherine TeyssierMichael R Stallcup
Aug 2, 2005·Cell Metabolism·Jiandie LinBruce M Spiegelman
Aug 2, 2005·Cell Metabolism·Joslyn K BrunelleNavdeep S Chandel
Jun 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Qinghong ZhangRichard H Goodman
Jun 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Zoltan AranyBruce M Spiegelman
Aug 8, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sara BorniquelMaría Monsalve
Sep 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Zhidan WuSusan C Stevenson
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Qinghong ZhangRichard H Goodman
Mar 10, 2007·The EMBO Journal·Zachary Gerhart-HinesPere Puigserver
May 2, 2007·Proceedings of the National Academy of Sciences of the United States of America·Lindsay M RohasBruce M Spiegelman
Jul 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sibylle JägerBruce M Spiegelman
Sep 15, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Steven D MasonRandall S Johnson
Oct 11, 2007·Science's STKE : Signal Transduction Knowledge Environment·Gregg L Semenza
Oct 13, 2007·The Journal of Biological Chemistry·Adam R WendeDaniel P Kelly
Feb 29, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Diana R GutsaevaClaude A Piantadosi
Mar 12, 2008·Developmental Cell·Peter FraislPeter Carmeliet
May 20, 2008·American Journal of Physiology. Heart and Circulatory Physiology·John J LehmanDaniel P Kelly

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Citations

Mar 1, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joel N BuxbaumDaniel R Salomon
Jul 23, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Yiping ZhangXiaoyu Zhang
Aug 31, 2016·Pflügers Archiv : European journal of physiology·E L PetersR T Jaspers
May 14, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christine CulpepperPaul J Rozance
May 13, 2015·Molecular and Cellular Biology·Shih Ying ChungShen Liang Chen
Feb 10, 2018·European Journal of Applied Physiology·Stefan De SmetPeter Hespel
Nov 17, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sina A GharibDavid Gozal
Sep 22, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Chiel de TheijeHarry R Gosker
Dec 7, 2011·Medicine and Science in Sports and Exercise·Zihong HeAlejandro Lucia
Feb 5, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Norbert F VoelkelHarm J Bogaard
Dec 11, 2019·Journal of Tissue Engineering and Regenerative Medicine·Jose Francisco IslasRobert J Schwartz
Dec 31, 2019·Oxidative Medicine and Cellular Longevity·Yingmu TongJingyao Zhang
Apr 9, 2013·International Journal of Cancer. Journal International Du Cancer·Ya-Ping Tsai, Kou-Juey Wu
Dec 30, 2020·Microvascular Research·Farina Mohamad YusoffYukihito Higashi
Jun 19, 2021·High Altitude Medicine & Biology·Dustin SlivkaBrent Ruby
Mar 16, 2011·Brain Research·Girriso F Benderro, Joseph C Lamanna
Nov 3, 2011·Journal of Molecular and Cellular Cardiology·Atsushi HoshinoHiroaki Matsubara

❮ Previous
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