Regulation of IGF-1 but not TGF-β1 by NGF in the smooth muscle of the inflamed urinary bladder.

Regulatory Peptides
Qing L Zhang, Li-Ya Qiao

Abstract

Intraperitoneal injection of cyclophosphamide (CYP) causes hemorrhagic cystitis with excess growth of muscular layer leading to bladder hypertrophy; this could be attributable to changes in the expression profiles of growth factors in the inflamed urinary bladder. The growth factors characterized in the current study include nerve growth factor (NGF), insulin-like growth factor (IGF)-1, and transforming growth factor (TGF)-β1. We found that following CYP injection for 8 h and 48 h, the mRNA levels of all three factors were increased in the inflamed bladder when compared to control. The level of NGF mRNA was mainly increased in the urothelium layer while the levels of IGF-1 mRNA and TGF-β1 mRNA were increased in the smooth muscle layer. The level of NGF high affinity receptor TrkA mRNA was also increased in both the urothelium and the smooth muscle layers during bladder inflammation. When we blocked NGF action with NGF neutralizing antibody in vivo, we found that the up-regulation of IGF-1 in the inflamed bladder was reversed while the up-regulation of TGF-β1 was not affected by NGF neutralization. The effect of NGF on regulating IGF-1 expression was further confirmed in bladder smooth muscle culture showing that exogenous NGF i...Continue Reading

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Citations

Dec 9, 2014·Frontiers in Biology·Li-Ya Qiao
Apr 17, 2014·BioMed Research International·Eric J GonzalezMargaret A Vizzard
Oct 10, 2014·British Journal of Pharmacology·A CoelhoL A Birder
May 29, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Donna SellersMartin C Michel
Mar 24, 2016·The Journal of Physiology·Eric J GonzalezMargaret A Vizzard

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