Regulation of IgM+ B Cell Activities by Rainbow Trout APRIL Reveals Specific Effects of This Cytokine in Lower Vertebrates

Frontiers in Immunology
Irene SoletoCarolina Tafalla

Abstract

Tumor necrosis factor ligand superfamily members such as B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) have been identified in mammals as key regulators of B cell homeostasis and activation. However, the immune functions of APRIL are not as well defined as those of BAFF. Furthermore, while BAFF is present in all vertebrates, APRIL is missing in some animal groups, suggesting that BAFF has compensated the functions of APRIL in these species. In this context, we thought of great interest to explore the effects of APRIL on teleost B cells, given that APRIL appears for the first time in evolution in bony fish. Thus, in this study, we have performed an extensive analysis of the effect of APRIL on B cells using rainbow trout (Oncorhynchus mykiss) as a model species. Our results demonstrate that APRIL induces a specific proliferation of IgM+ B cells by itself and increases IgM secretion without promoting a terminal differentiation to plasma cells. APRIL also increased the levels of surface MHC II and augmented the capacity of these cells to process antigen, effects that were exclusively exerted on IgM+ B cells. Although our results point to a highly conserved role of APRIL on B cell homeostasis and activa...Continue Reading

References

Sep 22, 1998·The Journal of Experimental Medicine·M HahneJ Tschopp
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·N BaumgarthL A Herzenberg
Feb 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Emanuela CastigliRaif S Geha
Dec 15, 2004·Journal of Virology·Rahnuma WahidMarie Chow
Apr 27, 2005·The Journal of Experimental Medicine·Karine IngoldPascal Schneider
May 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·John D HansenRuth B Phillips
May 12, 2005·Current Opinion in Immunology·Pascal Schneider
Aug 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Min YangAdrian T Ting
Feb 14, 2006·Nature Reviews. Drug Discovery·Stacey R DillonAnne J Novak
Apr 1, 2006·Cellular Immunology·Daniel Rodríguez-Pinto
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gavin W Glenney, Gregory D Wiens
Sep 28, 2007·European Journal of Immunology·Gijs HardenbergJan Paul Medema
Oct 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Van Trung ChuClaudia Berek
Mar 29, 2008·Annual Review of Immunology·Gislâine Martins, Kathryn Calame
Jun 26, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tiehui WangChristopher J Secombes
Aug 3, 2010·Nature Immunology·Yong-An ZhangJ Oriol Sunyer
Feb 28, 2013·Frontiers in Immunology·Vishal J SindhavaMichael P Cancro
May 23, 2013·Annals of the New York Academy of Sciences·Thomas L RothsteinHiroaki Kaku
Jun 14, 2013·Frontiers in Immunology·Dimitar B IlievJorunn B Jørgensen
Feb 12, 2014·Immunology Letters·Vishal J SindhavaMichael P Cancro
Feb 18, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lv-yun ZhuJian-zhong Shao
Jan 1, 2013·Annual Review of Animal Biosciences·David ParraJ Oriol Sunyer
Jul 17, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aitor G GranjaCarolina Tafalla
Aug 21, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sabyasachi DasBrantley R Herrin
Jan 16, 2017·Developmental and Comparative Immunology·Rosario CastroCarolina Tafalla
Mar 18, 2017·Fish & Shellfish Immunology·Irene SoletoAitor G Granja
Jun 6, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Beatriz AbósCarolina Tafalla

❮ Previous
Next ❯

Citations

Jul 29, 2020·Science China. Life Sciences·Yaoguo LiJun Zou
Mar 1, 2019·Protein and Peptide Letters·Xiu Li FengPu Yan Chen
Apr 12, 2019·Frontiers in Immunology·Rocío SimónCarolina Tafalla
Jun 17, 2020·Frontiers in Immunology·Liting WuJun Li
Mar 26, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rocío SimónCarolina Tafalla

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
FCS
FACS
protein assay
electrophoresis
flow cytometry
confocal microscopy
Assay
protease Assay
fluorescence microscopy

Software Mentioned

Image Lab Touch
Fiji
APRIL
FACS DIVA

Related Concepts

Related Feeds

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.