Regulation of IL-17A and implications for TGF-β1 comodulation of airway smooth muscle remodeling in severe asthma

American Journal of Physiology. Lung Cellular and Molecular Physiology
Jon M Evasovic, Cherie A Singer

Abstract

Severe asthma develops as a result of heightened, persistent symptoms that generally coincide with pronounced neutrophilic airway inflammation. In individuals with severe asthma, symptoms are poorly controlled by high-dose inhaled glucocorticoids and often lead to elevated morbidity and mortality rates that underscore the necessity for novel drug target identification that overcomes limitations in disease management. Many incidences of severe asthma are mechanistically associated with T helper 17 (TH17) cell-derived cytokines and immune factors that mediate neutrophilic influx to the airways. TH17-secreted interleukin-17A (IL-17A) is an independent risk factor for severe asthma that impacts airway smooth muscle (ASM) remodeling. TH17-derived cytokines and diverse immune mediators further interact with structural cells of the airway to induce pathophysiological processes that impact ASM functionality. Transforming growth factor-β1 (TGF-β1) is a pivotal mediator involved in airway remodeling that correlates with enhanced TH17 activity in individuals with severe asthma and is essential to TH17 differentiation and IL-17A production. IL-17A can also reciprocally enhance activation of TGF-β1 signaling pathways, whereas combined TH1/T...Continue Reading

References

Jan 1, 1982·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·S G Marketos, C N Ballas
Feb 19, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G SawyerR Beasley
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·H LiW I Wood
Jun 3, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·M M GrunsteinS Chuang
Nov 4, 2000·The Journal of Biological Chemistry·J LeeA L Gurney
Dec 6, 2000·American Journal of Respiratory Cell and Molecular Biology·Y GotoK Sekizawa
Dec 12, 2000·The Journal of Allergy and Clinical Immunology·W W BusseS E Wenzel
Feb 13, 2001·Immunity·Sean DiehlM Rincón
Sep 7, 2001·The Journal of Allergy and Clinical Immunology·S MoletJ Chakir
Nov 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·L S ChambersP R Johnson
May 23, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kazunori HataTadao Bamba
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen D HurstRobert L Coffman
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Trevor StarnesRobert Hromas
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xuefei MaMichel Laviolette
Mar 12, 2003·Chest·Paul M O'Byrne, Mark D Inman
Jun 10, 2003·Journal of Applied Physiology·Brent E McParlandPeter D Pare
Oct 31, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Bart M VanaudenaerdeGeert M Verleden
Apr 15, 2004·Allergy·Matthew MasoliUNKNOWN Global Initiative for Asthma (GINA) Program
Apr 24, 2004·American Journal of Respiratory Cell and Molecular Biology·Andrew J HalaykoJulian Solway
May 11, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nidhi S UndeviaSteven R White
Aug 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cheng-Yuan KaoReen Wu
Oct 14, 2004·The Journal of Allergy and Clinical Immunology·Sheridan HennessAlaina J Ammit
Dec 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kelan G TantisiraScott T Weiss
Jan 19, 2005·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yoshihiko Chiba, Miwa Misawa
Jan 26, 2005·American Journal of Respiratory Cell and Molecular Biology·Urpo LappalainenKristina Bry
Apr 30, 2005·Immunology Letters·Hidenori TakahashiHidetada Sasaki
Jun 18, 2005·Memórias do Instituto Oswaldo Cruz·Leonardo K TeixeiraJoão P B Viola
Oct 6, 2005·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Guanghui LiuBaozhu Li
Oct 11, 2005·Annual Review of Cell and Developmental Biology·Xin-Hua Feng, Rik Derynck
Dec 16, 2005·Chemical Immunology and Allergy·A Barry Kay
May 11, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sheridan HennessAlaina J Ammit
May 13, 2006·The Journal of Biological Chemistry·Blanca Camoretti-MercadoJulian Solway
May 23, 2006·Respiratory Medicine·Stephen P PetersColin Reisner
Jul 15, 2006·Chest·Sidney S Braman

❮ Previous
Next ❯

Citations

Apr 5, 2020·Clinical Reviews in Allergy & Immunology·Jefferson Russo VictorMaria Leite-de-Moraes
Jul 7, 2020·Frontiers in Immunology·Grzegorz KardasMichał Panek
Apr 12, 2020·Molecular and Cellular Endocrinology·Abril Carbajal-GarcíaLuis M Montaño
Feb 19, 2021·Journal of Leukocyte Biology·Chenglin GuoChun Chang
Apr 2, 2021·Kidney Research and Clinical Practice·David P BasilePurvi Mehrotra
Jun 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ayman M MousaSaleh A Almatroodi
Jul 2, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Qian YuYaFang Lou

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination
bronchoalveolar lavage
nuclear translocation
dissection
cells
bronchoalveolar
lavage

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.