Regulation of IL-18 in Helicobacter pylori infection

The Journal of Immunology : Official Journal of the American Association of Immunologists
Kazuyoshi YamauchiYoshio Yamaoka

Abstract

The gastric mucosal immune response is thought to be comprised predominantly of the Th1 type; however, there are limited data regarding the role of IL-18 in Helicobacter pylori-induced inflammation. We investigated IL-18 levels in gastric mucosal biopsy specimens as well as in isolated gastric epithelial cells and lamina propria mononuclear cells. We also investigated IL-18 levels in gastric epithelial cells and the monocyte cell line THP-1 cocultured with H. pylori. In both systems, IL-18 levels were markedly enhanced in H. pylori-infected epithelial cells and monocytes. IL-18 levels in H. pylori-infected gastric mucosa were well correlated with the severity of gastric inflammation, confirming that H. pylori-induced IL-18 plays an important role in gastric injury. Virulence factors of H. pylori; the cag pathogenicity island and OipA affected IL-18 induction in different manners. Up-regulation of IL-18 mRNA/protein in epithelial cells was dependent on both virulence factors. Interestingly, up-regulation of IL-18 mRNA in monocytes was independent of both factors, whereas IL-18 protein was OipA dependent-cag pathogenicity island independent, indicating that OipA regulates IL-18 induction in monocytes at the posttranscriptional le...Continue Reading

References

Aug 1, 1980·International Journal of Cancer. Journal International Du Cancer·S TsuchiyaK Tada
Aug 28, 1998·Gastroenterology·T WatanabeM Nakao
Jun 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y YamaokaD Y Graham
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·F LuzzaF Pallone
Apr 12, 2002·Biochemical and Biophysical Research Communications·Noriko KoyamaUwe Kalina
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ali A AkhianiNils Lycke
May 10, 2003·FEMS Immunology and Medical Microbiology·Andreas Munk Petersen, Karen Angeliki Krogfelt
Aug 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ali A AkhianiNils Lycke
Jan 5, 2005·Digestive Diseases and Sciences·Andrew S DayPhilip M Sherman
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nesrin OzörenGabriel Núñez

❮ Previous
Next ❯

Citations

Nov 27, 2010·Expert Review of Gastroenterology & Hepatology·Malin Sundquist, Marianne Quiding-Järbrink
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ghada AlsalehDominique Wachsmann
Dec 10, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Bekale N BenoitShun'ichiro Taniguchi
Sep 12, 2008·Helicobacter·Tamara VorobjovaTsutomu Chiba
Aug 12, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alain P GobertKeith T Wilson
Oct 25, 2014·Journal of Atherosclerosis and Thrombosis·Cong HeNong-Hua Lu
Sep 13, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Raphaela P SemperRaquel Mejías-Luque
Oct 23, 2009·Current Microbiology·Tania Beatriz Romero-AdriánAna Antúnez
Jun 13, 2020·Journal of Leukocyte Biology·Warrison A Andrade, Dario S Zamboni
Jul 1, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Purnima GhoseNahed Ismail
Aug 29, 2009·Helicobacter·Mario M D'Elios, Leif P Andersen
Dec 29, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Li-Jian ChenQi Wang
Oct 11, 2021·Journal of Molecular Biology·Madeline J ChurchillIsabella Rauch

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.