Regulation of IL-6 system in cerebrospinal fluid and serum compartments by seizures: the effect of seizure type and duration

Journal of Neuroimmunology
K A LehtimäkiJ Peltola

Abstract

Experimental studies suggest that cytokine production may be triggered by seizure activity. Here we determined the levels of interleukin-6 (IL-6) and its soluble receptor components (sIL-6R and sGp130) in CSF and serum from control subjects and patients after different types of seizures. IL-6 levels were increased after seizures, whereas sIL-6R levels were decreased. Interestingly, the levels of IL-6 were strongly increased after recurrent generalized tonic-clonic seizures (GTCS), whereas after single tonic-clonic or prolonged partial seizures IL-6 levels were increased to lesser extent. These results provide further support for a hypothesis of cytokine production induced by seizure activity per se.

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Citations

Nov 8, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Knut BiberH W G M Boddeke
Feb 19, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K A LehtimäkiJ Peltola
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Aug 1, 2012·Oxidative Medicine and Cellular Longevity·Carlos Clayton Torres AguiarSilvania Maria Mendes Vasconcelos
Aug 31, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Madeleine Sharp, Manouchehr Javidan
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Sep 4, 2013·Journal of Neuroimmunology·Suvi LiimatainenPeltola Jukka
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