PMID: 7025841Aug 1, 1981Paper

Regulation of immune reactivity to collagen in human beings

Arthritis and Rheumatism
A M Solinger, J D Stobo

Abstract

Denaturated beef collagen was tested for its ability to induce the production of leukocyte inhibition factor among the peripheral blood mononuclear cells from patients with rheumatoid arthritis and normal individuals. Responsiveness, defined as the production of leukocyte inhibition factor sufficient to cause greater than 20% inhibition of leukocyte migration, was significantly (P less than 0.001, X2 = 31.1) associated with HLA-DR4. All HLA-DR4 positive individuals, including subjects without any evidence of synovitis, were collagen responders. There was no significant (P = 0.3) difference in the absolute reactivity of HLA-DR4+ versus HLA-DR4- individuals to respond to another antigen, Candida albicans. Collagen reactivity required interactions between macrophages and T cells and was directed against determinants inherent in the linear polypeptide, (Gly-Pro)n. In 5 normal HLA-DR4- nonresponders tested, absence of discernable reactivity to collagen was associated with the presence of antigen-specific, radiosensitive suppressive T cells. These studies suggest that during the physiologic metabolism of collagen all individuals are exposed to Gly-Pro determinants normally buried in the interstices of the collagen triple helix. In in...Continue Reading

References

Aug 17, 1978·The New England Journal of Medicine·D E TrenthamJ R David
Sep 1, 1977·The Journal of Experimental Medicine·D E TrenthamA H Kang
Jun 22, 1972·Biochimica Et Biophysica Acta·R S BhatnagarS M Wolfe
Jan 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·T Z Liu, R S Bhatnagar
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A M SolingerJ D Stobo

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Citations

Apr 1, 1987·The American Journal of Medicine·T E ScottF M Wigley
Mar 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·O Anusaksathien, A E Dolby
May 1, 1990·Journal of Periodontology·A RefaieA E Dolby
Jan 1, 1987·Scandinavian Journal of Rheumatology. Supplement·T Egeland

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