PMID: 2484202Nov 1, 1989Paper

Regulation of immunity to extraembryonic antigens in human pregnancy

American Journal of Reproductive Immunology : AJRI
D S TorryJ A McIntyre

Abstract

Pregnancy results in the immunologic challenge of the female to a wide variety of allogeneic antigens. Particular attention has been given to antibodies directed to allotypic trophoblast antigens (TLX), for trophoblast form the true allograft interface between mother and fetus. Studies found that antibodies to paternal TLX allotypes are produced in women suffering from secondary recurrent abortions. These TLX antibodies are not directed to classical HLA private epitopes. In this report, treatment of lymphocytes with papain to remove HLA Class I did not decrease TLX antigen densities. These results suggest TLX antibodies are not directed to Class I epitopes, public or private. The allotypic nature of TLX antigens requires that a pregnant female must be able to regulate TLX immune responses to avoid rejection of the conceptus. One mechanism to specifically and systemically regulate TLX immunity is the idiotype anti-idiotype network. We provide preliminary evidence in this report for the presence of TLX idiotype network in a normal primigravida. Initially, no antipaternal TLX antibodies were detected in the serum of the primigravida, suggesting no TLX immunization had occurred. However, separation of Ab1 from Ab2 by absorption of ...Continue Reading

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Citations

Jan 1, 1991·Histochemistry·M CastellucciR Chiquet-Ehrismann
Apr 1, 1991·American Journal of Reproductive Immunology : AJRI·W P Faulk, C A Labarrere
Apr 1, 1991·American Journal of Reproductive Immunology : AJRI·C B CoulamJ A McIntyre
May 1, 1991·American Journal of Reproductive Immunology : AJRI·D S TorryJ A McIntyre
Oct 1, 1992·American Journal of Reproductive Immunology : AJRI·J A McIntyre
Feb 12, 1998·American Journal of Reproductive Immunology : AJRI·C A Mullen
Jan 1, 1992·Transfusion Medicine Reviews·A M Unander

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