PMID: 8959941Nov 1, 1996Paper

Regulation of immunomodulatory functions by granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in vivo

Annals of Hematology
M J AmanC Peschel

Abstract

The present study was designed to investigate in vivo immunomodulatory properties of hematopoietic growth factors. The influence on the activation of cytokine synthesis and on the expression of surface antigens associated with cellular activation of G-CSF or GM-CSF was investigated in cancer patients receiving these factors. One single dose of growth factor was administered to patients with bladder cancer (G-CSF group) or small cell lung cancer (GM-CSF group) before chemotherapy. After cytoreductive chemotherapy patients received supportive therapy with G-CSF or GM-CSF. Peripheral blood mononuclear cells and plasma samples were obtained for flow cytometry, Northern blot analysis, and assessment of cytokine protein levels after single-dose as well as after continuous cytokine administration. Our results demonstrate differences in the induction of biological activities by GM-CSF and G-CSF in vivo which correlate well with in vitro findings. Among mature hematopoietic cells the effect of G-CSF is restricted to the granulocyte lineage. With GM-CSF moderate but unequivocal modulation of monocyte function was observed. On peripheral blood monocytes expression of MHC class-II molecules and CD44 was markedly stimulated. After one singl...Continue Reading

Citations

Dec 11, 2002·Journal of Neurochemistry·Christoph D SchmidMonica J Carson
Mar 20, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·T TretterC Peschel
Dec 7, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Stefan KasperThomas Fischer
Mar 4, 2006·Onkologie·Dominik RüttingerKarl-Walter Jauch
Mar 14, 2002·Expert Opinion on Biological Therapy·Michael L Salgaller
Jan 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David W Sternberg, D Gary Gilliland
Dec 4, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Barbara Mroczko, Maciej Szmitkowski
Apr 22, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Barbara MroczkoGrazyna Jurkowska

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