Regulation of inflammatory and lipid metabolism genes by eicosapentaenoic acid-rich oil.

Journal of Lipid Research
Peter J GilliesJohn P Vanden Heuvel

Abstract

Omega-3-PUFAs, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), are associated with prevention of various aspects of metabolic syndrome. In the present studies, the effects of oil rich in EPA on gene expression and activation of nuclear receptors was examined and compared with other ω3-PUFAs. The EPA-rich oil (EO) altered the expression of FA metabolism genes in THP-1 cells, including stearoyl CoA desaturase (SCD) and FA desaturase-1 and -2 (FASDS1 and -2). Other ω3-PUFAs resulted in a similar gene expression response for a subset of genes involved in lipid metabolism and inflammation. In reporter assays, EO activated human peroxisome proliferator-activated receptor α (PPARα) and PPARβ/γ with minimal effects on PPARγ, liver X receptor, retinoid X receptor, farnesoid X receptor, and retinoid acid receptor γ (RARγ); these effects were similar to that observed for purified EPA. When serum from a 6 week clinical intervention with dietary supplements containing olive oil (control), DHA, or two levels of EPA were applied to THP-1 cells, the expression of SCD and FADS2 decreased in the cells treated with serum from the ω3-PUFA-supplemented individuals. Taken together, these studies indicate regulation of gene expression by...Continue Reading

References

Oct 13, 1995·The Journal of Biological Chemistry·K YuM A Lazar
Oct 31, 2001·Public Health Nutrition·S Renaud, D Lanzmann-Petithory
Jun 26, 2002·The American Journal of Clinical Nutrition·Eric DewaillyBruce John Holub
Jun 29, 2002·Cellular and Molecular Life Sciences : CMLS·A K HihiW Wahli
Nov 28, 2002·JAMA : the Journal of the American Medical Association·Frank B Hu, Walter C Willett
Dec 14, 2002·Journal of the American College of Nutrition·Artemis P Simopoulos
Jan 9, 2003·Annual Review of Physiology·Gordon A FrancisJohan Auwerx
Aug 31, 2004·The Journal of Nutrition·Paul Cohen, Jeffrey M Friedman
Sep 25, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Bela F AsztalosErnst J Schaefer
Jul 14, 2005·Annual Review of Nutrition·Harini Sampath, James M Ntambi
Jan 18, 2006·Annual Review of Medicine·Simon W Beaven, Peter Tontonoz
Jul 11, 2006·Breast Cancer Research and Treatment·Rasha HammamiehMarti Jett
Jul 18, 2006·The American Journal of Clinical Nutrition·Sarah K GebauerPenny M Kris-Etherton
Oct 19, 2007·Journal of Cardiovascular Medicine·Walter C Willett
Apr 22, 2008·Expert Opinion on Pharmacotherapy·Ann C Skulas-RayPenny M Kris-Etherton
May 28, 2008·Molecular Nutrition & Food Research·Philip C Calder
May 1, 2009·Genes & Nutrition·Marijana RadonjicBen van Ommen
Jun 12, 2009·The American Journal of Clinical Nutrition·Mark BouwensLydia A Afman
May 4, 2010·Nature Chemical Biology·Alison L GroegerFrancisco J Schopfer
Jun 1, 2010·The Proceedings of the Nutrition Society·Michael JamesLes Cleland
Jun 25, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·W C TuR A Gibson
Jul 27, 2010·Advanced Drug Delivery Reviews·Ira G Schulman
Feb 11, 2011·Science Translational Medicine·Przemyslaw SapiehaLois E H Smith
Jul 23, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Alexandra MontagnerWalter Wahli

❮ Previous
Next ❯

Citations

Jun 25, 2013·Journal of Physiology and Biochemistry·Silvia Lorente-CebriánMaría J Moreno-Aliaga
Apr 20, 2014·Physiological Reports·Yolanda F OteroOwen P McGuinness
Aug 29, 2012·Expert Opinion on Therapeutic Targets·Philippe Gervois, Roxane M Mansouri
Jan 29, 2014·Human Psychopharmacology·Isabelle BauerDavid Crewther
Aug 25, 2015·BioMed Research International·Joseph SchwagerNorman Salem
Aug 1, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Katie B PaulKevin M Crofton
Oct 14, 2016·Metabolism: Clinical and Experimental·Ivor B AsztalosErnst J Schaefer
Sep 29, 2017·Nutrients·Cristina Aguirre-PortolésAna Ramírez de Molina
Feb 16, 2018·Frontiers in Molecular Neuroscience·Anne VejuxGérard Lizard
Jun 24, 2017·Therapeutic Advances in Cardiovascular Disease·Yogita RochlaniJawahar L Mehta
Mar 22, 2014·Molecular and Clinical Oncology·Pinar O EserJerry T Thompson

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.