Regulation of inflammatory pathways in schizophrenia: A comparative study with bipolar disorder and healthy controls

European Psychiatry : the Journal of the Association of European Psychiatrists
L García-ÁlvarezJ Bobes

Abstract

Immune-inflammatory processes have been implicated in schizophrenia (SCH), but their specificity is not clear. To identify potential differential intra-/intercellular biochemical pathways controlling immune-inflammatory response and their oxidative-nitrosative impact on SCH patients, compared with bipolar disorder (BD) patients and healthy controls (HC). Cross-sectional, naturalistic study of a cohort of SCH patients (n=123) and their controls [BD (n=102) and HC (n=80)]. ANCOVA (or Quade test) controlling for age and gender when comparing the three groups, and controlling for age, gender, length of illness, cigarettes per day, and body mass index (BMI) when comparing SCH and BD. Pro-inflammatory biomarkers: Expression of COX-1 was statistically higher in SCH and BD than HC (P<0.0001; P<0.0001); NFκB and PGE2 were statistically higher in SCH compared with BD (P=0.001; P<0.0001) and HC (P=0.003; P<0.0001); NLRP3 was higher in BD than HC (P=0.005); and CPR showed a gradient among the three groups. Anti-inflammatory biomarkers: BD patients had lower PPARγ and higher 15d-PGJ2 levels than SCH (P=0.005; P=0.008) and HC (P=0.001; P=0.001). Differences between SCH and BD: previous markers of SCH (NFκB and PGE2) and BD (PPARγ and 15d-PGJ...Continue Reading

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Citations

Oct 9, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·L García-ÁlvarezJ Bobes
Jul 4, 2019·Current Psychiatry Reports·Peter F Buckley
Jun 30, 2019·Psychiatry and Clinical Neurosciences·Miquel BioqueMiquel Bernardo
Feb 26, 2020·European Psychiatry : the Journal of the Association of European Psychiatrists·Ángela VelascoPilar A Sáiz
May 7, 2020·Asian Journal of Psychiatry·Keisuke MiyamotoShu-Ichi Ueno
Aug 11, 2021·World Neurosurgery·Xiangyu LiuTaibao Qian

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