Regulation of influenza virus infection by long non-coding RNAs

Virus Research
Sara Landeras-Bueno, Juan Ortín

Abstract

Influenza A viruses generate annual epidemics and occasional pandemics of respiratory disease with important consequences for human health and economy. To establish a productive infection, influenza viruses interact with cellular factors to favour their own replication and to suppress antiviral cell responses. Although most virus-host interaction studies have been centred on cell protein factors, most of the human transcriptome comprises non-coding RNAs, as miRNAs and lncRNAs. The latter are key cellular regulators in many cellular processes, including transcriptional and post-transcriptional regulation. Influenza virus infection induces the differential expression of hundreds of potential lncRNAs, some of which are related to the antiviral pathways activated by the cell while others may be deregulated by the infection to allow efficient virus multiplication. Although our knowledge on the role of cellular lncRNAs for influenza virus replication and pathogenesis is still at its infancy, several lncRNAs have been described to influence the cell innate response to the virus by altering the histone modification at specific sites, by interaction with specific transcription factors or directly stimulating in cis the expression of spe...Continue Reading

References

Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·W Du, T Maniatis
Apr 25, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T IwamuraT Fujita
May 23, 2002·American Journal of Human Genetics·Barbara R MigeonHeather Carpenter
May 8, 2004·Nature Reviews. Genetics·John S Mattick
Jul 9, 2004·Carcinogenesis·Anna IacoangeliHenri Tiedge
Sep 6, 2005·Science·P CarninciUNKNOWN RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Jun 9, 2006·The Journal of General Virology·Sougata SahaPundi N Rangarajan
Mar 28, 2007·Genome Research·Jasmina PonjavicGerton Lunter
Feb 27, 2008·Molecular and Cellular Biology·Faizaan MohammadChandrasekhar Kanduri
Mar 4, 2008·Molecular Cell·Peter D MarinerJames A Goodrich
Mar 29, 2008·Science·Paulo P AmaralJohn S Mattick
Sep 18, 2008·The Journal of General Virology·Benjamin G HaleDavid Jackson
Dec 17, 2008·Genomics·Rodrigo LouroSergio Verjovski-Almeida
Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yasnory T F SasakiTetsuro Hirose
Feb 26, 2009·Cell·Chris P PontingWolf Reik
Mar 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Petro YakovchukJennifer F Kugel
Jul 21, 2009·Epigenetics : Official Journal of the DNA Methylation Society·Faizaan MohammadChandrasekhar Kanduri
Jun 22, 2010·Nature Structural & Molecular Biology·Iván D'Orso, Alan D Frankel
Jul 10, 2010·Science·Miao-Chih TsaiHoward Y Chang
Aug 24, 2010·Human Molecular Genetics·Maite Huarte, John L Rinn
Dec 15, 2010·Trends in Immunology·Iris K Pang, Akiko Iwasaki
Jan 18, 2011·Virology·Jeremy S Rossman, Robert A Lamb
Mar 2, 2011·RNA Biology·Patricia Resa-InfanteJuan Ortin
Aug 20, 2011·Wiley Interdisciplinary Reviews. RNA·B Matija PeterlinDavid H Price
Sep 20, 2011·Molecular Cell·Kevin C Wang, Howard Y Chang
Oct 4, 2011·Virus Research·J H C M KreijtzG F Rimmelzwaan
Mar 20, 2012·Current Opinion in Genetics & Development·Yesu JeonJeannie T Lee
Apr 12, 2012·Nucleic Acids Research·Victoria A MoranAhmad M Khalil
Apr 27, 2012·Journal of Physiology and Biochemistry·Yong HuangQuan Zou
Jun 12, 2012·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zu-Yau Lin, Wan-Long Chuang

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Citations

Dec 31, 2016·International Journal of Molecular Sciences·Yanmei MaJi-Long Chen
Jun 15, 2018·Journal of Virology·Wenjia ChaiXin Ye
Oct 11, 2017·The American Journal of Tropical Medicine and Hygiene·Xiao-Jun WangHong-Juan Peng
Jun 17, 2020·Emerging Microbes & Infections·Jing Wang, Shan Cen
Apr 2, 2020·Frontiers in Cellular and Infection Microbiology·Shuang LuWei Hou
Apr 4, 2019·Nature Communications·Pengfei ZhangMian Wu
Jan 28, 2020·International Journal of Molecular Medicine·Wen YanXinhua Wang
Jan 7, 2021·RNA Biology·Gayan BamunuarachchiLin Liu
Mar 27, 2021·Veterinary Research·Linlin FangXianWei Wang

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