Regulation of innate and adaptive immune responses by the related cytokines IL-12, IL-23, and IL-27.

Archivum Immunologiae Et Therapiae Experimentalis
Carol Beadling, Mark K Slifka

Abstract

The functional characterization and subsequent purification of T cell growth factor/interleukin (IL)-2 in the early 1980s established this secreted protein as a key mediator of immune cell activation and provided the prototype that enabled the discovery of numerous cytokines over the ensuing two decades. While soluble immunoregulatory factors were initially identified functionally as biological activities present in the culture supernatants of activated lymphocytes/monocytes, this methodology shifted radically following the completion of the human genome sequence. Computer-generated structural modeling algorithms have replaced functional assays and biochemical purification as the initial means of discovering new cytokines. To date, a total of 31 interleukins, as well as over a dozen other related hematopoietic factors, have been identified. These cytokines and their receptors may be grouped on the basis of structural homologies as well as by shared ligand and receptor subunits. The challenge now at hand is to define the biological functions of the newly identified cytokines and to elucidate the common and divergent roles of related family members. This point is well illustrated by the IL-12/IL-23/IL-27 family, whose members sha...Continue Reading

Citations

Nov 10, 2007·Clinical Reviews in Allergy & Immunology·Heidi GoodarziRichard L Gallo
Apr 25, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I Leonard BernsteinUNKNOWN American College of Allergy, Asthma and Immunology
Jun 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Bailey E FreemanMark K Slifka
Jan 18, 2007·The Journal of Experimental Medicine·Jianguo LiuXiaojing Ma
Apr 15, 2003·Clinical Microbiology Reviews·Francine Marciano-Cabral, Guy Cabral
Feb 26, 2011·Clinical & Developmental Immunology·Celso Martins Queiroz-JuniorTarcília Aparecida da Silva
Mar 13, 2014·Cell Communication and Signaling : CCS·Joo-Yong Jung, Cory M Robinson
Feb 4, 2014·Clinics and Research in Hepatology and Gastroenterology·Nasser Ebrahimi DaryaniNima Rezaei
May 19, 2010·International Journal of Molecular Sciences·Therwa HamzaBingyun Li
Aug 2, 2014·Immunological Investigations·Mansour ShajarianHoda Mohammad Dezashibi
Feb 27, 2014·Expert Opinion on Therapeutic Targets·Andrea ChiricozziJames G Krueger
Aug 19, 2014·International Immunopharmacology·Ahmed G Abdel SalamMona F Schaalan
Apr 1, 2011·Arthritis and Rheumatism·Francesco CicciaGiovanni Triolo
Nov 3, 2011·Immunology·Chunlei TangWenlong Huang
Jul 13, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·Christopher E M Griffiths, Giampiero Girolomoni
Jun 11, 2009·International Journal of Andrology·B FibbiM Maggi
Feb 5, 2010·The British Journal of Dermatology·J RenneM Wittmann
Nov 14, 2015·Medical Microbiology and Immunology·Panthong KulsantiwongPongsak Utaisincharoen
Apr 29, 2015·Toxicon : Official Journal of the International Society on Toxinology·Reza HadaddezfuliSamahir Saadi
Apr 6, 2013·Cytokine·Joo-Yong Jung, Cory M Robinson
Sep 7, 2012·Biochimica Et Biophysica Acta·Heesun NamRon F Morrison
Sep 19, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Patricia Méndez-Samperio
Aug 30, 2008·The International Journal of Biochemistry & Cell Biology·Zi Yan TanShisan Bao
Mar 8, 2011·The Journal of Allergy and Clinical Immunology·Mübeccel AkdisCezmi A Akdis
Apr 25, 2013·Journal of Reproductive Immunology·Francesco Lotti, Mario Maggi
Apr 18, 2014·Journal of Virology·Bailey E FreemanMark K Slifka
Jul 11, 2008·Genes and Immunity·G ManciniG Gallagher
Oct 1, 2016·Nature Reviews. Urology·Cosimo De NunzioAndrea Tubaro
Sep 14, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Miaomiao HouXinyi Li
Oct 21, 2011·Molecular and Cellular Biochemistry·Chao RongFei-hu Chen
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amir F SheibanieDoina Ganea
Dec 29, 2020·The Journal of International Medical Research·Jing-Jing Zhu, Ning-Ning Shan
Jul 6, 2021·Indian Journal of Clinical Biochemistry : IJCB·Priya AllimuthuJesudas Blessed Raj
Jun 19, 2021·Frontiers in Pharmacology·Chun-Ping LiuHong-Xing Liu
Sep 28, 2021·Frontiers in Immunology·Joy Manohar SibiVivekanandhan Aravindhan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.