Regulation of insulin and adipokinetic hormone/glucagon production in flies.

Wiley Interdisciplinary Reviews. Developmental Biology
Muhammad AhmadNorbert Perrimon

Abstract

Metabolic homeostasis is under strict regulation of humoral factors across various taxa. In particular, insulin and glucagon, referred to in Drosophila as Drosophila insulin-like peptides (DILPs) and adipokinetic hormone (AKH), respectively, are key hormones that regulate metabolism in most metazoa. While much is known about the regulation of DILPs, the mechanisms regulating AKH/glucagon production is still poorly understood. In this review, we describe the various factors that regulate the production of DILPs and AKH and emphasize the need for future studies to decipher how energy homeostasis is governed in Drosophila. This article is categorized under: Invertebrate Organogenesis > Flies Signaling Pathways > Global Signaling Mechanisms.

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Citations

May 26, 2020·Cellular and Molecular Life Sciences : CMLS·Takashi KoyamaKim Rewitz
Aug 28, 2020·Frontiers in Endocrinology·Sifang Liao, Dick R Nässel
Apr 3, 2020·The Journal of Experimental Biology·Thomas Roeder
Jan 24, 2021·Scientific Reports·Surya BanerjeeJennifer Curtiss
Mar 9, 2021·PLoS Genetics·Meet ZandawalaDick R Nässel
Jun 5, 2021·Biophysical Journal·Prabhat TiwariTimothy E Saunders
Jul 17, 2021·Frontiers in Physiology·Szymon ChowańskiJoanna Pacholska-Bogalska
Jul 31, 2021·Current Biology : CB·Dennis PaulsChristian Wegener
Aug 23, 2020·Cell and Tissue Research·Dick R Nässel, Meet Zandawala

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