Regulation of interleukin-13 receptor constituents on mature human B lymphocytes.

The Journal of Biological Chemistry
H OgataA L Maizel

Abstract

Human B cells stimulated through both their immunoglobulin and CD40 receptors up-regulate 745 +/- 51 interleukin (IL)-13 ligand binding sites with an affinity of 0.91 +/- 0.08 nM within 24 h. IL-13 binds primarily to the IL-13Ralpha1 with subsequent sequestration of the IL-4Ralpha into the complex. IL-13Ralpha1 may also be found in those receptors capable of binding IL-4. gamma chain (gammac) participates in receptors capable of binding IL-4 but is not found in association with bound IL-13. Dimeric receptors composed of the IL-4Ralpha complexed with either the IL-13Ralpha1 or gammac occur simultaneously within defined B cell populations. mRNAs for all receptor constituents are increased subsequent to immunoglobulin stimulation alone, while maximal expression of IL-13Ralpha1 is more dependent upon co-stimulation of immunoglobulin and CD40 receptors. mRNA levels for IL-13Ralpha1 vary over a wider range subsequent to surface stimulation than other receptor components. Although gammac is not bound to IL-13 in B cells under the conditions evaluated, it may influence IL-13 binding by competing with IL-13Ralpha1 for association/sequestration with the IL-4Ralpha chain. IL-13Ralpha2 does not participate in the IL-13 receptor that is up-...Continue Reading

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Citations

Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·S R HusainR K Puri
Dec 4, 2003·Biochemical and Biophysical Research Communications·Mamoru YoshikawaHirohisa Saito
Jan 1, 2009·Respiratory Research·Barry J MoynihanSophie Laberge
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Aug 28, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Kenji Izuhara
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Apr 22, 2003·The Journal of Allergy and Clinical Immunology·Gurjit K Khurana Hershey

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