PMID: 9657254Jul 10, 1998Paper

Regulation of interleukin-6, and macrophage colony-stimulating factor mRNA levels by histamine in stromal cell line (MC3T3-G2/PA6)

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
S Takamatsu, K Nakano

Abstract

The aim of this study was to examine the role of histamine in regulation of IL-6 and M-CSF gene expression in bone marrow stromal cells. Total cellular synthesis was also estimated for IL-6. The effects of the amine were evaluated using the stromal cell line, MC3T3-G2/PA6 (PA6). Histamine caused a distinct accumulation of IL-6 mRNA in the cells, whereas it decreased M-CSF transcripts. Both pyridylethylamine, a H1 agonist, and dimaprit, a H2 agonist, caused a large increase in the level of IL-6 mRNA in PA6 cells. The histamine-induced expression of IL-6 mRNA was associated with enhanced secretion of IL-6, as determined by ELISA. These results, together with the results of our previous studies, suggest that histamine produced by stromal macrophages differentially regulates the production of IL-6 and M-CSF in other kinds of stromal cells and hence promotes differentiation and/or proliferation of hematopoietic progenitor cells.

Citations

May 19, 2000·Cell Biology International·K GadóA Falus
Oct 22, 2002·Biochemical and Biophysical Research Communications·Yoshiaki DeyamaKuniaki Suzuki
Aug 11, 2001·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·K Nakano, S Takamatsu

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