PMID: 9162522Apr 1, 1996Paper

Regulation of interleukin-6 expression in porcine immune cells

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
R ScamurraM P Murtaugh

Abstract

Interleukin-6 (IL-6) is a pleiotropic cytokine that regulates the immune response, acute-phase reaction, and hematopoiesis. As a first step in studying the actions of IL-6 in pigs, the regulation of IL-6 expression was examined in various swine cells, including a fibroblast cell line, peripheral blood mononuclear cells (PBMC), and alveolar macrophages. IL-6 expression in transformed swine testicular (TST) fibroblasts was enhanced by TNF and IL-1 beta and to a lesser extent by poly(I).(C) and LPS. IL-6 was induced in porcine PBMC by either LPS or PHA; however, the combination of LPS plus PHA resulted in maximal IL-6 expression. Furthermore, in PBMC cells separated by adherence, LPS was a more potent inducer than PHA in adherent cells, whereas PHA was more potent in nonadherent cells. Alveolar macrophages collected from different pigs could be divided into low and high responders with respect to IL-6 induction by LPS. IL-6 mRNA induction by LPS could be detected in only 6 of 20 donor animals. Other inflammatory cytokines (IL-8, IL-beta, and TNF) were readily induced by LPS in alveolar macrophages from both low and high responders. Treatment of low-responder alveolar macrophages with conditioned medium containing IFN-gamma did not...Continue Reading

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Citations

Jul 19, 2000·Infection and Immunity·D F MorrisonM P Murtaugh
Jan 23, 2009·Veterinary Immunology and Immunopathology·Wasin Charerntantanakul
Sep 2, 2008·Developmental and Comparative Immunology·Michael P MurtaughYaling Zhou
Oct 15, 2005·Journal of Immunological Methods·J C DuvigneauM Gemeiner
Mar 1, 2012·Veterinary Immunology and Immunopathology·Mohammad Ariful IslamKarl Schellander
Nov 29, 2005·Veterinary Immunology and Immunopathology·Hui-Wen ChangVictor F Pang
Jul 12, 2005·Veterinary Pathology·P J Sánchez-CordónJ C Gómez-Villamandos
Jul 4, 2007·American Journal of Veterinary Research·Pedro J Sánchez-CordónJosé C Gómez-Villamandos

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