Regulation of intestinal mast cells and luminal protein release by cerebral thyrotropin-releasing hormone in rats

Gastroenterology
J SantosJ R Malagelada

Abstract

Intestinal mast cell activity is modulated by the central nervous system, but the mechanisms are not well established. The aim of this study was to investigate whether cerebral thyrotropin-releasing hormone (TRH) activates intestinal mast cells and to elucidate the mechanisms involved, specifically, the contribution of mast cells to vagally stimulated luminal protein release. In anesthetized rats, mast cell activation was assessed by measuring the release of the specific mucosal rat mast cell protease II (RMCP II) and prostaglandin (PG) D2 into the intestinal lumen. Luminal protein release was measured as an index of epithelial permeability to macromolecules. Intracisternal injection of the TRH analogue RX 77368 (30 ng) induced a transient increase in intestinal release of RMCP II and PGD2 that was abolished by dox-antrazole. RX 77368-stimulated RMCP II release was also abolished by vagotomy and reduced by atropine by 65%. However, both systemic capsaicin and indo-methacin enhanced RMCP II release. RX 77368-stimulated luminal protein release was abolished by vagotomy and reduced by doxantrazole. Central vagal activation by TRH stimulates intestinal mast cell secretion, in part via peripheral muscarinic receptors, and is modulat...Continue Reading

Citations

Jul 11, 2012·Nature Reviews. Gastroenterology & Hepatology·Babette PeetersRaoul C M Hennekam
Mar 5, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P VergaraC Juanola
Apr 19, 2003·Journal of Gastroenterology and Hepatology·Ashkan FarhadiAli Keshavarzian
Aug 20, 2002·Journal of Clinical Gastroenterology·Jackie D Wood
Apr 18, 2007·Journal of Clinical Gastroenterology·Jackie D Wood
Aug 24, 1999·Gut·J D WoodP L Andrews
Nov 13, 2008·Pharmacology & Therapeutics·J KamathA Winokur
Apr 18, 1998·Gastroenterology·J SantosJ R Malagelada
Oct 23, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Takashi JohMakoto Itoh
Aug 10, 2005·The American Journal of Gastroenterology·Ashkan FarhadiJeremy Z Fields
Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·M E KreisD Grundy
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Aug 13, 1999·The American Journal of Physiology·J SantosM H Perdue
Feb 24, 2001·Annals of the New York Academy of Sciences·J GrootM Perdue
Aug 10, 2004·Gastroenterology·Jackie D Wood

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