PMID: 6025551Jun 2, 1967Paper

Regulation of intracellular sodium concentrations in rat diaphragm muscle

Science
H A Fozzard, D M Kipnis

Abstract

The concept is suggested that the sodium pump mechanism is influenced by the transmembrane electrical potential, and that the pump acts to maintain a constant electrochemical gradient for sodium. Evidence leading to this suggestion was obtained in rat diaphragm muscle by altering systematically the transmembrane chemical gradient for sodium ions and the transmembrane voltage. The voltage changes were produced by varying the extracellular and intracellular potassium ion concentrations. In each case the intracellular sodium concentration changed, presumably by activity of the sodium pump, so that the total electrochemical gradient for sodium was restored.

References

Feb 1, 1961·The Journal of Physiology·E J CONWAYJ A ZADUNAISKY
Mar 1, 1963·The Journal of General Physiology·L J MULLINS, A S FRUMENTO
Dec 1, 1963·The Journal of Physiology·R P KERNAN
Oct 1, 1964·The Journal of Clinical Investigation·J E PARRISH, D M KIPNIS
Jan 1, 1965·The Journal of General Physiology·P HOROWICZ, C J GERBER
May 1, 1965·The Journal of Physiology·R D KEYNES
May 1, 1965·The Journal of General Physiology·L J MULLINS, M Z AWAD
May 1, 1965·The Journal of General Physiology·E PAGE, S R STORN
Oct 1, 1959·The Journal of Physiology·A L HODGKIN, P HOROWICZ
Oct 1, 1959·The Journal of Physiology·R D KEYNES, R C SWAN
Oct 1, 1951·The American Journal of Physiology·H B STEINBACH
Apr 1, 1949·Physiological Reviews·H H USSING

❮ Previous
Next ❯

Citations

Jan 1, 1982·The Journal of Membrane Biology·P C Maloney
May 1, 1973·Biological Reviews of the Cambridge Philosophical Society·R F Burton
Aug 13, 1971·Biochimica Et Biophysica Acta·I Bihler, P C Sawh
Mar 15, 1988·Biochemical Pharmacology·S N Murthy, A Lavy
Jan 1, 1969·Pflügers Archiv : European journal of physiology·H Scholz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.