Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha

The Biochemical Journal
Patrick J PollardPeter J Ratcliffe

Abstract

The transcription factor HIF (hypoxia-inducible factor) mediates a highly pleiotrophic response to hypoxia. Many recent studies have focused on defining the extent of this transcriptional response. In the present study we have analysed regulation by hypoxia among transcripts encoding human Fe(II)- and 2-oxoglutarate-dependent oxygenases. Our results show that many of these genes are regulated by hypoxia and define two groups of histone demethylases as new classes of hypoxia-regulated genes. Patterns of induction were consistent across a range of cell lines with JMJD1A (where JMJD is Jumonji-domain containing) and JMJD2B demonstrating robust, and JMJD2C more modest, up-regulation by hypoxia. Functional genetic and chromatin immunoprecipitation studies demonstrated the importance of HIF-1alpha in mediating these responses. Given the importance of histone methylation status in defining patterns of gene expression under different physiological and pathophysiological conditions, these findings predict a role for the HIF system in epigenetic regulation.

References

May 9, 2000·The Journal of Biological Chemistry·Y TakahashiT Miura
Oct 13, 2001·Science·R K Bruick, S L McKnight
Sep 18, 2003·Nature Reviews. Cancer·Gregg L Semenza
Nov 19, 2003·European Journal of Biochemistry·Karl-Heinz HofbauerArmin Kurtz
May 23, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Takashi TakeuchiShunzo Kondo
Jun 2, 2006·Genes & Development·Barna D FodorThomas Jenuwein
Sep 21, 2006·Nature Reviews. Genetics·Robert J KloseYi Zhang
Dec 30, 2006·Molecular and Cellular Biology·Ritu KulshreshthaMircea Ivan
Jan 16, 2007·Molecular Cell·Yang Shi, Johnathan R Whetstine
Feb 13, 2007·Mutation Research·Amber Buescher Johnson, Michelle Craig Barton
Oct 20, 2007·Science·Bingsheng ChangRichard K Bruick
Feb 19, 2008·Nature Chemical Biology·Christoph Loenarz, Christopher J Schofield
Feb 21, 2008·Nature Reviews. Molecular Cell Biology·M Celeste Simon, Brian Keith
Feb 26, 2008·Mutation Research·Amber Buescher JohnsonMichelle Craig Barton
May 24, 2008·Molecular Cell·William G Kaelin, Peter J Ratcliffe
Jun 10, 2008·Biochemical and Biophysical Research Communications·Sven WellmannChristoph Bührer

❮ Previous
Next ❯

Citations

Feb 9, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Christian FrezzaEyal Gottlieb
Aug 8, 2009·Cell and Tissue Research·Johanna Myllyharju, Ernestina Schipani
Dec 4, 2010·Cell Death and Differentiation·A B HjelmelandJ N Rich
Mar 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Xiaobo XiaAndrew L Kung
Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jes-Niels BoeckelStefanie Dimmeler
Nov 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Weibo LuoGregg L Semenza
Jul 1, 2009·The Journal of Biological Chemistry·Twan van den BeuckenBradly G Wouters
Sep 15, 2011·The Journal of Biological Chemistry·Lars HillringhausUdo Oppermann
Aug 5, 2009·Antioxidants & Redox Signaling·David R Mole
Feb 26, 2013·Nucleic Acids Research·Kelly CoffeyCraig N Robson
Nov 14, 2013·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Leah C Young, Michael J Hendzel
May 17, 2011·Molecular Cancer Research : MCR·Qun LinZhong Yun
Aug 30, 2013·Journal of Biomedical Science·Claudio MuscariCarlo Guarnieri
Aug 17, 2011·International Journal of Molecular Sciences·Joel I Perez-PerriPablo Wappner
Feb 21, 2014·Molecular Biology of the Cell·Ioannis KasioulisPatricia L Yeyati
Jun 10, 2014·Ageing Research Reviews·Antero SalminenKai Kaarniranta
Jan 5, 2011·Mediators of Inflammation·Claudio BrigatiMassimo Romani
Oct 11, 2011·Cellular and Molecular Life Sciences : CMLS·Francisco Javier Rodríguez-Jiménez, Victoria Moreno-Manzano
Feb 15, 2012·Cellular and Molecular Life Sciences : CMLS·Floriane Nicol-BenoîtDenis Michel
Mar 5, 2013·Cellular and Molecular Life Sciences : CMLS·Fulvio ChiacchieraDiego Pasini
Aug 21, 2015·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Jessica A WarnsArchana Dhasarathy
Apr 2, 2016·Current Pharmacology Reports·Lakshmanan JagannathanMax Costa
Jun 19, 2012·Seminars in Cancer Biology·Chuan Shen, William G Kaelin
Jan 23, 2016·Molecular Aspects of Medicine·Mun Chiang ChanPeter J Ratcliffe
Oct 12, 2013·Science China. Life Sciences·Hui YangKunLiang Guan
Apr 3, 2015·Epigenomics·Rebecca L HancockAkane Kawamura
May 7, 2009·Autism Research : Official Journal of the International Society for Autism Research·Valerie W HuNorman H Lee
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Gregg L Semenza
Mar 24, 2016·Proceedings of the National Academy of Sciences of the United States of America·Chuanzhao ZhangGregg L Semenza
Mar 4, 2014·Epigenomics·Catrine JohanssonUdo Oppermann
Oct 2, 2015·Genes·Shaliny RamachandranEster M Hammond
Feb 12, 2015·Clinical Science·Smriti Murali KrishnaJonathan Golledge
Aug 26, 2014·The Biochemical Journal·Alena ShmakovaSonia Rocha
Oct 25, 2012·The Biochemical Journal·Elena M Sánchez-FernándezEmily Flashman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.