Regulation of KIF2A by Antitumor miR-451a Inhibits Cancer Cell Aggressiveness Features in Lung Squamous Cell Carcinoma

Cancers
Akifumi UchidaHiromasa Inoue

Abstract

In the human genome, miR-451a is encoded close to the miR-144 on chromosome region 17q11.2. Our previous study showed that both strands of pre-miR-144 acted as antitumor miRNAs and were involved in lung squamous cell carcinoma (LUSQ) pathogenesis. Here, we aimed to investigate the functional significance of miR-451a and to identify its targeting of oncogenic genes in LUSQ cells. Downregulation of miR-451a was confirmed in LUSQ clinical specimens, and low expression of miR-451a was significantly associated with poor prognosis of LUSQ patients (overall survival: p = 0.035, disease-free survival: p = 0.029). Additionally, we showed that ectopic expression of miR-451a significantly blocked cancer cell aggressiveness. In total, 15 putative oncogenic genes were shown to be regulated by miR-451a in LUSQ cells. Among these targets, high kinesin family member 2A (KIF2A) expression was significantly associated with poor prognosis (overall survival: p = 0.043, disease-free survival: p = 0.028). Multivariate analysis showed that KIF2A expression was an independent prognostic factor in patients with LUSQ (hazard ratio = 1.493, p = 0.034). Aberrant KIF2A expression promoted the malignant transformation of this disease. Analytic strategies ba...Continue Reading

References

Feb 16, 1999·Cell·A DesaiC E Walczak
Aug 11, 2004·The Journal of Cell Biology·Neil J Ganem, Duane A Compton
Apr 25, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Alex G LittleAndrew K Stewart
Mar 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eva BandresJesus Garcia-Foncillas
Oct 31, 2009·International Journal of Cancer. Journal International Du Cancer·Somesh Baranwal, Suresh K Alahari
Jan 30, 2010·Seminars in Cell & Developmental Biology·Stephanie C Ems-McClung, Claire E Walczak
Oct 5, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Junko KikuchiHirotoshi Dosaka-Akita
Nov 8, 2011·Clinics in Chest Medicine·William D Travis
May 17, 2012·World Journal of Radiology·Saeed MirsadraeeEdwin van Beek
Sep 17, 2013·Cancer Science·Hirofumi YoshinoNaohiko Seki
May 17, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David R GandaraFred R Hirsch
May 23, 2015·Nature Reviews. Cancer·Shuibin Lin, Richard I Gregory
Jun 14, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiangjun FanZhiwei Wang
Aug 5, 2016·Journal of Human Genetics·Keiko MizunoHiromasa Inoue
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators
Feb 18, 2017·Nature Reviews. Drug Discovery·Rajesha Rupaimoole, Frank J Slack
Jun 7, 2017·The New England Journal of Medicine·Solange PetersUNKNOWN ALEX Trial Investigators
Nov 21, 2017·The New England Journal of Medicine·Jean-Charles SoriaUNKNOWN FLAURA Investigators
Feb 11, 2018·Biochemical and Biophysical Research Communications·Tian XieChongjun Zhong

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Citations

May 30, 2019·Journal of Cellular Physiology·Monireh KhordadmehrBehzad Baradaran
Dec 18, 2020·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Tianling DingRuoyu Deng
Dec 24, 2019·Seminars in Cancer Biology·Devesh TewariAnupam Bishayee
Mar 14, 2021·Clinics and Research in Hepatology and Gastroenterology·Wenjuan LiuPeng Kang
Jun 3, 2021·Biomolecules·Jaroslav NunvarRuth Tachezy

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Datasets Mentioned

BETA
GSE19188
SK-MES-1
GSE113066
GSE123318

Methods Mentioned

BETA
flow cytometry
transfection
Reverse Transcription Polymerase Chain
Assay

Software Mentioned

SPSS
TargetScanHuman

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