Regulation of leptin synthesis and secretion before birth: implications for the early programming of adult obesity

Reproduction : the Official Journal of the Society for the Study of Fertility
I C McMillenB S Muhlhausler

Abstract

A series of epidemiological, clinical and experimental studies have shown that there are associations between the fetal and neonatal nutritional environment and the amount and distribution of adipose tissue in adult life. This review considers the evidence for these relationships and discusses the potential impact of the prenatal nutritional experience on the development of the endocrine and neuroendocrine systems that regulate energy balance, with a particular emphasis on the role of the adipocyte-derived hormone, leptin. In the rodent, leptin derived from the mother may exert an important influence on the development of the appetite regulatory neural network and on the subsequent regulation of leptin synthesis and the risk for obesity in the offspring. In species such as the human and sheep, there is also recent evidence that the synthesis and secretion of adipocyte-derived hormones, such as leptin, are regulated in fetal life. Furthermore, the hypothalamic neuropeptides that regulate energy intake and expenditure in adult life are also present within the fetal brain and may be regulated by the prevailing level of maternal and hence fetal nutrient and hormonal signals, including leptin. This work is important in determining t...Continue Reading

References

Sep 1, 1978·The American Journal of Physiology·L B Oscai, J A McGarr
Oct 1, 1978·Australian Journal of Biological Sciences·R T Gemmell, G Alexander
Aug 12, 1976·The New England Journal of Medicine·G P RavelliM W Susser
Jan 1, 1992·Experimental and Clinical Endocrinology·A PlagemannG Dörner
Jun 1, 1992·Journal of Epidemiology and Community Health·C M LawS J Simmonds
Dec 1, 1991·Diabetes·B L SilvermanB E Metzger
Jan 7, 1995·BMJ : British Medical Journal·C H FallS Duggleby
Feb 18, 1995·BMJ : British Medical Journal·C H FallT W Meade
May 1, 1994·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G Dörner, A Plagemann
Jul 16, 1996·Biochemical and Biophysical Research Communications·T J KiefferJ F Habener
Sep 15, 1996·Circulation·G C CurhanM J Stampfer
May 1, 1997·The Journal of Clinical Endocrinology and Metabolism·J MatsudaY Kuroda
Dec 31, 1997·BMJ : British Medical Journal·H T SørensenT I Sørensen
Oct 31, 1998·Nature·J M Friedman, J L Halaas
Mar 27, 1999·Biochemical Society Transactions·M E Symonds, T Stephenson
Apr 14, 1999·Journal of Neuroendocrinology·L M WilliamsN Hoggard
Nov 11, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·D I PhillipsP C Owens
Dec 10, 1999·The Journal of Endocrinology·B S YuenP C Owens
Jan 25, 2000·American Journal of Physiology. Endocrinology and Metabolism·T J Kieffer, J F Habener
May 11, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·I S OkosunR S Cooper
Jul 14, 2000·American Journal of Physiology. Endocrinology and Metabolism·M H VickersP D Gluckman
Sep 21, 2000·Trends in Endocrinology and Metabolism : TEM·R S Ahima, J S Flier
Oct 13, 2001·Hormone Research·P TapanainenM Knip
Oct 24, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R J LoosR Vlietinck
Dec 12, 2001·Molecular and Cellular Endocrinology·B H BreierW P Wong

❮ Previous
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Citations

Jan 2, 2010·European Journal of Nutrition·C-Y Oliver ChenDonald E Smith
Oct 22, 2010·Current Diabetes Reports·Sharon J Herring, Emily Oken
Apr 20, 2007·The British Journal of Nutrition·Aml ErhumaAndrew J Bennett
Nov 1, 2010·Animal : an International Journal of Animal Bioscience·J L SartinR R Wilborn
Apr 2, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L AttigJ Djiane
Jul 26, 2013·Pediatric Research·Sylvia A Obermann-BorstRégine P M Steegers-Theunissen
Jan 24, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Amanda N Sferruzzi-PerriAbigail L Fowden
Aug 20, 2011·Diabetes, Obesity & Metabolism·S J HerringE Oken
Jun 17, 2011·Neuroendocrinology·Robert J DenverGraham C Boorse
Aug 9, 2007·The Journal of Clinical Endocrinology and Metabolism·Catharine R GaleCyrus Cooper
Sep 18, 2008·PloS One·Cristianne R M FrazierJeff A Beeler
Apr 15, 2008·Journal of Pediatric Endocrinology & Metabolism : JPEM·M Martha Vela-HuertaJavier Hernnández
Dec 6, 2012·ISRN Pediatrics·Claudia Eberle, Christoph Ament
Oct 30, 2013·Nutrition Reviews·Dana Dabelea, Curtis S Harrod
Feb 6, 2013·Nutrition & Diabetes·J C Jones-SmithL C H Fernald
Feb 26, 2013·Cellular and Molecular Life Sciences : CMLS·Mary-Elizabeth Patti
Aug 3, 2012·European Journal of Pediatrics·Polyxeni KarakostaLeda Chatzi
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Mark H Vickers
Aug 11, 2015·Journal of Clinical Nursing·Mary Carolan-OlahJulia Lechuga
Jun 9, 2009·Obstetrics and Gynecology Clinics of North America·Emily Oken
Jul 1, 2008·Physiology & Behavior·Floor RemmersHenriette A Delemarre-van de Waal
Feb 19, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Wieland KiessJürgen Kratzsch
Aug 11, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sorina Grisaru-GranovskyDeborah Elstein
Dec 16, 2006·Experimental Physiology·P D Taylor, L Poston
Aug 13, 2013·Paediatric and Perinatal Epidemiology·Polyxeni KarakostaLeda Chatzi
Jun 18, 2009·American Journal of Human Biology : the Official Journal of the Human Biology Council·Irfan AhmadFeizal Waffarn
Aug 17, 2016·European Journal of Endocrinology·Carol Ní ChaoimhMairead Kiely
Mar 10, 2016·Ciência & saúde coletiva·Regina Célia Nucci Pontellide Sonia Valle Walter Borges Oliveira
Apr 9, 2010·The American Journal of Clinical Nutrition·Dominique RoberfroidUNKNOWN Micronutriments et Santé de la Mère et de l'Enfant Study (MISAME) Group
May 3, 2018·Physiological Reviews·Charles A DucsayLubo Zhang
Sep 19, 2017·Journal of Animal Science and Biotechnology·Prabhat Khanal, Mette Olaf Nielsen
Dec 6, 2018·Pediatric Obesity·Chantel L MartinAnna Maria Siega-Riz
May 18, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sarah J SpencerQuentin J Pittman
Nov 6, 2010·Endocrine Reviews·Floor Remmers, Henriette A Delemarre-van de Waal
Jul 12, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Antonio Pérez-PérezVíctor Sánchez-Margalet
Nov 3, 2016·The Journal of Nutrition·Chantel L MartinAlison M Stuebe

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