Regulation of leukocyte function by citric acid cycle intermediates

Journal of Leukocyte Biology
Naeem K PatilEdward R Sherwood

Abstract

Cellular metabolism is a means of generating ATP to provide energy for key cellular functions. However, recent research shows that citric acid cycle intermediates target vital cellular functions of the innate immune system. Succinate, itaconate, citrate, and fumarate have been shown to mediate or regulate important myeloid cell functions during infection and inflammation. This review covers the regulatory functions of citric acid cycle intermediates in myeloid cells and discusses potential translational applications, key mechanistic questions, and future research directions.

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Citations

Oct 28, 2019·Reviews in Endocrine & Metabolic Disorders·Sonia Fernández-Veledo, Joan Vendrell
Jun 18, 2020·Frontiers in Immunology·Margaret A McBrideNaeem K Patil
Oct 31, 2020·Cellular and Molecular Life Sciences : CMLS·Inaya HayekAnja Lührmann
Aug 12, 2019·Free Radical Biology & Medicine·Mohammed AlquraishiAhmed Bettaieb
Nov 7, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Antonio HernandezJulia K Bohannon
May 15, 2021·PLoS Pathogens·Marco Tulio R GomesSergio C Oliveira
Jul 14, 2021·Environment International·E ColicinoR J Wright
Aug 7, 2021·Biomedicines·Ezequiel MonferrerTomás Álvaro Naranjo

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