Regulation of liver development: implications for liver biology across the lifespan

Journal of Molecular Endocrinology
Philip A Gruppuso, Jennifer A Sanders

Abstract

The liver serves a spectrum of essential metabolic and synthetic functions that are required for the transition from fetal to postnatal life. Processes essential to the attainment of adequate liver mass and function during fetal life include cell lineage specification early in development, enzymic and other functional modes of differentiation throughout gestation, and ongoing cell proliferation to achieve adequate liver mass. Available data in laboratory rodents indicate that the signaling networks governing these processes in the fetus differ from those that can sustain liver function and mass in the adult. More specifically, fetal hepatocytes may develop independent of key mitogenic signaling pathways, including those involving the Erk mitogen-activated protein kinases MAPK1/3 and the mechanistic target of rapamycin (mTOR). In addition, the fetal liver is subject to environmental influences that, through epigenetic mechanisms, can have sustained effects on function and, by extension, contribute to the developmental origin of adult metabolic disease. Finally, the mitogen-independent phenotype of rat fetal hepatocytes in late gestation makes these cells suitable for cell-based therapy of liver injury. In the aggregate, studies ...Continue Reading

References

Jan 1, 1985·Biology of the Neonate·F Mayor, J M Cuezva
Jan 1, 1988·Pediatric Pathology·G M Hutchins, G W Moore
Jun 1, 1985·Diabetes·J B Susa, R Schwartz
Jul 17, 1973·Biochemical and Biophysical Research Communications·T B MillerJ Larner
May 1, 1974·The Biochemical Journal·P Devos, H G Hers
Dec 1, 1973·The Journal of Clinical Investigation·J R GirardR Assan
Nov 1, 1993·Experimental Cell Research·T R CurranP A Gruppuso
Dec 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N FaustoE M Webber
Mar 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y HarunaM A Gerber
Sep 28, 2001·The Journal of Biological Chemistry·J M BoylanP A Gruppuso
Sep 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Padmanabhan AnandPhilip A Gruppuso
Jul 20, 2005·Differentiation; Research in Biological Diversity·Silvia NavaSuchitra Sumitran-Holgersson
Oct 21, 2006·Biochemical Society Transactions·D B Sacks
Jan 5, 2007·Annual Review of Immunology·Ana Cumano, Isabelle Godin
May 1, 2007·Annual Review of Nutrition·Robert A Waterland, Karin B Michels
Mar 12, 2008·Cancer Metastasis Reviews·Stephen M Keyse
May 20, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Sophie Collardeau-Frachon, Jean-Yves Scoazec
Jun 21, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Philip A GruppusoJennifer A Sanders
Feb 18, 2010·Developmental Cell·Karim Si-TayebStephen A Duncan
Dec 16, 2010·Nature Reviews. Molecular Cell Biology·Roberto ZoncuDavid M Sabatini
May 31, 2011·Aging·Susan E OzanneMiguel Constância
Apr 17, 2012·Cell·Mathieu Laplante, David M Sabatini

❮ Previous
Next ❯

Citations

Nov 30, 2016·Human Gene Therapy·Lisa M KattenhornSamuel C Wadsworth
Jan 24, 2019·Stem Cells and Development·Nikola SobočanFloriana Bulić-Jakuš
Jul 28, 2017·Transplantation·Joan M BoylanJennifer A Sanders
Feb 14, 2020·Genome Research·Tongqing GongYi Wang
Nov 12, 2017·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·John C Chapin, Paul Edward Monahan
Feb 8, 2021·Metabolomics : Official Journal of the Metabolomic Society·Nipun SainiSusan M Smith
Nov 8, 2017·Current Biology : CB·Elijah TreftsDavid H Wasserman
Jun 23, 2018·Gene Expression·Edward HurleyJennifer A Sanders

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

American Journal of Physiology. Endocrinology and Metabolism
Padmanabhan AnandPhilip A Gruppuso
© 2022 Meta ULC. All rights reserved