Regulation of major histocompatibility complex class II gene expression in trophoblast cells

Reproductive Biology and Endocrinology : RB&E
Shawn P MurphyRenae Holtz

Abstract

Trophoblast cells are unique because they are one of the few mammalian cell types that do not express major histocompatibility complex (MHC) class II antigens, either constitutively or after exposure to IFN-gamma. The absence of MHC class II antigen expression on trophoblast cells has been postulated to be one of the essential mechanisms by which the semi-allogeneic fetus evades immune rejection reactions by the maternal immune system. Consistent with this hypothesis, trophoblast cells from the placentas of women suffering from chronic inflammation of unknown etiology and spontaneous recurrent miscarriages have been reported to aberrantly express MHC class II antigens. The lack of MHC class II antigen expression on trophoblast cells is due to silencing of expression of the class II transactivator (CIITA), a transacting factor that is essential for constitutive and IFN-gamma-inducible MHC class II gene transcription. Transfection of trophoblast cells with CIITA expression vectors activates both MHC class II and class Ia antigen expression, which confers on trophoblast cells both the ability to activate helper T cells, and sensitivity to lysis by cytotoxic T lymphocytes. Collectively, these studies strongly suggest that stringent...Continue Reading

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Oct 4, 2005·Nature Reviews. Immunology·Walter ReithJean-Marc Waldburger
Oct 31, 2009·The International Journal of Developmental Biology·Elizabeth S TaglauerMargaret G Petroff
Jan 1, 2012·Case Reports in Nephrology·Ali Kemal KadiroğluM Emin Yılmaz
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Apr 9, 2021·Immunological Investigations·Yousef YousefzadehMehdi Yousefi
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Methods Mentioned

BETA
transfection
immunoprecipitation
acetylation
histone acetylation
footprinting
nuclear translocation

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