Regulation of mammalian sperm motility

Archives of Andrology
C B Lindemann, K S Kanous


The physiological regulation of sperm motility has become more amendable to investigation since the demonstration that cAMP and calcium play a role in modulating the functioning of the flagellar axoneme. Although the external triggering mechanisms that initiate motility and capacitation are still unknown, evidence supports a modification of the calcium balance by gated Ca2+ channels, accompanied by shifts in the internal pH. Ca2+ and pH may in turn act indirectly through cAMP and cAMP-dependent kinase (kinase(a] to control the phosphorylation state of functional proteins in the flagellar axoneme. The role of calcium is of central importance, but it is clear that several separate Ca2+-dependent mechanisms are involved. Ca2+ controls the curvature of the sperm flagellum and, so, can change the motility of the sperm from progressive swimming to tumbling. Under the appropriate conditions, calcium appears to have the capacity to deactivate motility by activating phosphodiesterase and phosphatase. The deactivating effect of Ca2+ may be offset under some circumstances by coactivation of adenyl cyclase, so phosphorylation of the axoneme and the motility are maintained. The specific factors determining the predominant calcium effect are...Continue Reading


Jan 1, 1976·Archives of Biochemistry and Biophysics·J P GrayE W Sutherland
Dec 1, 1976·Archives of Biochemistry and Biophysics·C A HermanB J Campbell
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R V Hyne, D L Garbers
Nov 1, 1978·Biology of Reproduction·H BrandtD D Hoskins
Dec 1, 1979·Biology of Reproduction·R V Hyne, D L Garbers
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·I R GibbonsW J Tang
Jan 20, 1975·Biochemical and Biophysical Research Communications·F Y Tang, D D Hoskins
Jun 15, 1975·Experientia·G V ShahS S Rao
Aug 1, 1979·Journal of Ultrastructure Research·J L Courtens, S Fournier-Delpech
Aug 1, 1979·Biology of Reproduction·T A Stewart, I T Forrester
Aug 1, 1979·Archives of Biochemistry and Biophysics·R H HammerstedtR P Amann
Jun 1, 1978·The Journal of Experimental Zoology·H I Calvin
Jun 29, 1978·Biochemical and Biophysical Research Communications·H P JonesM J Cormier
Sep 1, 1978·Biology of Reproduction·T A Stewart, I T Forrester
Dec 1, 1976·Journal of Ultrastructure Research·B BaccettiA G Burrini
May 1, 1988·Archives of Biochemistry and Biophysics·P S Chaudhry, E R Casillas
May 1, 1988·The Journal of Cell Biology·N M Bonini, D L Nelson
Jul 1, 1986·The Journal of Cell Biology·G E WardV D Vacquier
Jan 1, 1985·Current Topics in Cellular Regulation·B M ShapiroT Kazazoglou
Jul 1, 1985·Journal of Reproduction and Fertility·P RossiR Geremia
May 1, 1986·Biology of Reproduction·J E Schollmeyer
Jun 22, 1987·Biochimica Et Biophysica Acta·Y TajimaY Sugita
Nov 1, 1987·The Journal of Experimental Zoology·S S SuarezM W Ceglia
Apr 7, 1988·Biochimica Et Biophysica Acta·P Ben-AvH Breitbart
Jan 1, 1988·Cell Motility and the Cytoskeleton·C B Lindemann, J S Goltz
Feb 1, 1988·The Biochemical Journal·J A Cox
Jun 1, 1988·Biology of Reproduction·J J ParrishN L First
Dec 1, 1987·Biology of Reproduction·C E Coronel, H A Lardy
Jan 1, 1987·Cell Motility and the Cytoskeleton·D Eshel, C J Brokaw

❮ Previous
Next ❯


Nov 1, 1990·The Journal of Cell Biology·L H BookbinderV D Vacquier
Dec 1, 1994·The Journal of Cell Biology·D R HowardW S Sale
Jan 1, 2010·Biology of Reproduction·Kathleen A LesichCharles B Lindemann
Oct 20, 2012·PloS One·Sheena E M LewisMauro Maccarrone
Nov 1, 1993·Archives of Andrology·A Bhattacharyya, A Pakrashi
Jan 1, 1991·Annals of the New York Academy of Sciences·P Olds-Clarke
Jul 30, 2014·Biochimica Et Biophysica Acta·Victor D VacquierCarmen Beltrán
Mar 31, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Rubén D Peralta-AriasFulgencio Proverbio
Jul 1, 1996·Zentralblatt für Veterinärmedizin. Reihe A·A JanuskauskasH Rodriguez-Martinez
Oct 22, 2016·Cytoskeleton·Charles B Lindemann, Kathleen A Lesich
Dec 22, 2006·Biology of Reproduction·Becky Marquez, Susan S Suarez
Jan 28, 1998·Molecular Reproduction and Development·K AshizawaY Tsuzuki
May 7, 1999·Molecular Reproduction and Development·F AokiK Kohmoto
Dec 1, 1996·Molecular Reproduction and Development·M A Garcia, S Meizel
Nov 8, 1993·FEBS Letters·K D HinschK Aktories
Aug 31, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Ievgeniia GazoJanet Chenevert
Jan 3, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·K AshizawaY Tsuzuki
Jun 1, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·K AshizawaY Tsuzuki
Jan 1, 1991·Cell Motility and the Cytoskeleton·C B LindemannK S Kanous
Sep 1, 1995·Molecular Reproduction and Development·P K Schoff, N L First
Jan 1, 1992·Cell Motility and the Cytoskeleton·C Chevrier, J L Dacheux
Jun 1, 1991·Molecular Reproduction and Development·V Giroux-WidemannD Feneux
Nov 17, 2019·Reproduction in Domestic Animals = Zuchthygiene·Viviane Maria CodognotoEunice Oba
Dec 11, 2002·Andrologia·G M Trentalance, N B Beorlegui
Mar 21, 1998·Molecular Reproduction and Development·L KeskesD Feneux
Feb 21, 1997·The Journal of Biological Chemistry·S VijayaraghavanD W Carr

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.