Regulation of mastomys ECL cell function by transforming growth factor alpha

The Journal of Surgical Research
G P LawtonI M Modlin

Abstract

Little progress has been made in the understanding of the pathobiology of gastric neoplasia over the past 4 decades. This reflects the paucity of information available regarding the biology of gastric mucosal cell proliferation. More recently it has become apparent that growth factor regulation of cell proliferation is of considerable relevance in initiating mucosal mitogenesis. We have recently identified the histamine secreting enterochromaffin-like (ECL) cell as a pivotal cellular regulator of gastric acid secretion. In addition to its critical role in initiating acid secretion, we have proposed that the ECL cell may produce agents responsible for the regulation of mucosal cell proliferation. We have therefore hypothesized that such a function may be subserved by production of transforming growth factor alpha (TGFalpha). TGFalpha is known to play a significant role both in normal physiology and in the transformation of naive cells into a neoplastic form. We therefore proposed that increased levels of gastrin induced by low acid states might stimulate TGFalpha secretion and that this agent might be capable of regulating ECL cell DNA synthesis and cell proliferation. We used the mastomys rodent to generate an in vivo hypergast...Continue Reading

Citations

Dec 4, 2010·Journal of Biomedicine & Biotechnology·Reidar FossmarkHelge L Waldum
Apr 11, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Koji NozakiJames R Goldenring
Nov 28, 2008·Scandinavian Journal of Gastroenterology·Karin BakkelundHelge L Waldum
May 20, 2004·Cancer Research·Reidar FossmarkHelge L Waldum

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