Regulation of maternal thyroid during pregnancy

The Journal of Clinical Endocrinology and Metabolism
D GlinoerB Lejeune

Abstract

A prospective study was undertaken in 606 healthy women during pregnancy to evaluate the changes occurring in maternal thyroid economy as a result of 1) the increased thyroid hormone-binding capacity of serum, 2) the effects of increased levels of hCG on TSH and on the thyroid, and 3) a marginally low iodine intake in the population (50-75 micrograms/day). Four main features were observed. First, thyroidal activity adjusted to the marked increase in serum T4-binding globulin: pregnancy was accompanied by an overall reduction in the T4/T4-binding globulin ratio, with lower free T4 and T3 levels, although in most cases free hormone levels remained within the normal range. The adjustment of thyroidal output of T4 and T3 did not occur similarly in all subjects. In approximately one third of the women, there was relative hypothyroxinemia, higher T3/T4 ratios (presumably indicating preferential T3 secretion), and higher, although normal, serum TSH concentrations. Second, high hCG levels were associated with thyroid stimulation, both functionally (lower serum TSH) and anatomically (increased thyroid size). The data are consistent with a TSH-like effect of hCG on the thyroid. Hence, regulation of the maternal thyroid is complex, result...Continue Reading

Citations

Dec 2, 2004·Indian Journal of Pediatrics·Priyali PathakPreeti Singh
Nov 18, 2005·Archives of Gynecology and Obstetrics·Tomoaki MurataToshiyuki Takeshita
Oct 30, 2012·Archives of Gynecology and Obstetrics·Brigitte K BudenhoferBettina Toth
Aug 21, 2013·Journal of Assisted Reproduction and Genetics·Shauna ReinblattHananel Holzer
Sep 3, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Anibal AguayoItxaso Rica
Dec 25, 2002·Clinical Biochemistry·Offie Porat Soldin
May 24, 2003·Comprehensive Psychiatry·Miki BlochDavid R Rubinow
May 10, 2002·Chemosphere·Thomas A McDonald
Jul 11, 2001·Endocrinology and Metabolism Clinics of North America·J R Stockigt
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Daniel Glinoer
Dec 31, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Rutila CastañedaHomero Martínez
Jun 12, 2003·BJOG : an International Journal of Obstetrics and Gynaecology·Simon KaneColin Close
Jun 10, 2010·Nature Reviews. Endocrinology·Daniel Glinoer, Carole A Spencer
Sep 26, 2012·Nature Reviews. Endocrinology·Alex Stagnaro-Green, Elizabeth Pearce
Aug 26, 1998·Clinical Endocrinology·M F WescheN J Smits
Jul 1, 1993·British Journal of Obstetrics and Gynaecology·B LejeuneD Glinoer
Jun 1, 1993·British Journal of Obstetrics and Gynaecology·R HallJ H Lazarus
Nov 14, 2012·Gynecologic and Obstetric Investigation·Thibault LepoutreChantal Daumerie
Mar 9, 2010·BMC Endocrine Disorders·Marcus M CranstonStephanie K Brodine
Jun 21, 2011·BMC Research Notes·Anthony U MbahWinston C Ugbajah
Jun 23, 2009·Journal of Endocrinological Investigation·M MoletiF Trimarchi
Feb 6, 2014·Journal of Endocrinological Investigation·Rosario PivonelloGaetano Lombardi
Apr 24, 2014·Indian Journal of Clinical Biochemistry : IJCB·Rituparna MajiHarendra Nath Das
May 1, 1993·Journal of Endocrinological Investigation·J H Lazarus
Jan 1, 1996·Journal of Endocrinological Investigation·N AminoY Hidaka
Jul 27, 2011·Journal of Thyroid Research·Vimal NambiarNalini S Shah
Jul 26, 2011·Journal of Thyroid Research·Alexander M Goldman, Jorge H Mestman
Aug 8, 2013·British Medical Bulletin·Anukul Garg, Mark P J Vanderpump
Jan 1, 1995·Cancer Causes & Control : CCC·M R GalantiB Pettersson
Dec 3, 2009·Journal of Women's Health·Juan C Galofre, Terry F Davies
Jan 1, 1995·Baillière's Clinical Endocrinology and Metabolism·R Hall
Aug 3, 2005·The Journal of Clinical Investigation·Terry F DaviesRauf Latif

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