Regulation of MDK expression in human cancer cells modulates sensitivities to various anticancer drugs: MDK overexpression confers to a multi-drug resistance

Cancer Letters
Hio Chung KangJae-Gahb Park

Abstract

MDK is a heparin-binding growth factor associated with cancer development. Here, we sought to examine the association of MDK expression with resistance and sensitivity to different chemotherapeutic agents. We established stable HeLa cell transfectants (HeLa-MDK) and tested for decreased sensitivity to chemotherapeutic agents (5-FU, doxorubicin, and cisplatin). In addition, we used siRNA to block MDK expression in SNU-638 human gastric cancer cells and examined the chemosensitizing effect. HeLa-MDK cells treated with 5-FU, doxorubicin, and cisplatin showed a fold increase in the average IC(50) and an increased cell survival. siRNA-based knockdown of MDK expression in SNU-638 cells decreased the average IC(50) by 18-44% in cells treated with three drugs. Further investigations on the molecular mechanism should be clarified, but these results indicate that MDK up- and down-regulation appears to be capable of changing the chemosensitivities of cancer cells and MDK may have possible importance as a candidate therapeutic molecule.

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Citations

Sep 5, 2009·PloS One·Douglas M RuderferLeonid Kruglyak
Sep 17, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ning ZhangWei-Shan Chen
Jun 22, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Pijus K SasmalAkhil R Chakravarty
Dec 28, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Sovan RoyAkhil R Chakravarty
Oct 7, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Basudev MaityAkhil R Chakravarty
Apr 5, 2014·Molecular Medicine Reports·Wei LiXuemin Wang
Mar 10, 2009·Inorganic Chemistry·Sounik SahaAkhil R Chakravarty
May 3, 2021·European Journal of Medicinal Chemistry·Meizhu WangWen Zhou
Sep 25, 2021·Cancer Cell International·Beiquan HuDonghua Zou

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