Abstract
MDK is a heparin-binding growth factor associated with cancer development. Here, we sought to examine the association of MDK expression with resistance and sensitivity to different chemotherapeutic agents. We established stable HeLa cell transfectants (HeLa-MDK) and tested for decreased sensitivity to chemotherapeutic agents (5-FU, doxorubicin, and cisplatin). In addition, we used siRNA to block MDK expression in SNU-638 human gastric cancer cells and examined the chemosensitizing effect. HeLa-MDK cells treated with 5-FU, doxorubicin, and cisplatin showed a fold increase in the average IC(50) and an increased cell survival. siRNA-based knockdown of MDK expression in SNU-638 cells decreased the average IC(50) by 18-44% in cells treated with three drugs. Further investigations on the molecular mechanism should be clarified, but these results indicate that MDK up- and down-regulation appears to be capable of changing the chemosensitivities of cancer cells and MDK may have possible importance as a candidate therapeutic molecule.
References
Nov 5, 1997·Neuroscience Letters·K MishimaT Kirino
Apr 6, 1999·Carcinogenesis·H SakitaniY Konishi
Mar 4, 2000·Nature Genetics·U ScherfJ N Weinstein
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·J E StauntonT R Golub
Nov 21, 2001·Japanese Journal of Cancer Research : Gann·I HaraS Kamidono
Jan 10, 2002·Cancer Gene Therapy·J G WesselingD T Curiel
Jan 31, 2002·Annual Review of Medicine·Michael M Gottesman
Feb 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G FerrandinaF O Ranelletti
Apr 18, 2002·The Journal of Biological Chemistry·Yoshifumi TakeiTakashi Muramatsu
Aug 16, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G FerrandinaG Scambia
Sep 3, 2002·Journal of Biochemistry·Takashi Muramatsu
Sep 28, 2002·Urology·Chang-Ho LeeSang Eun Lee
Jan 21, 2004·Cancer Letters·Jinsoo ChungSang Eun Lee
Jan 22, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hio Chung KangJae-Gahb Park
Mar 12, 2004·Cancer Letters·Kenji Kadomatsu, Takashi Muramatsu
Jul 13, 2004·Annals of the New York Academy of Sciences·Ioannis P Trougakos, Efstathios S Gonos
Sep 17, 2004·The Journal of Urology·Yoichi MizutaniTsuneharu Miki
Dec 4, 2004·International Journal of Cancer. Journal International Du Cancer·Yoshifumi TakeiTakashi Muramatsu
Citations
Jan 16, 2010·Molecular Pharmaceutics·Danielle S W BenoitPatrick S Stayton
Sep 5, 2009·PloS One·Douglas M RuderferLeonid Kruglyak
Nov 26, 2010·Cancer Letters·Bo SunJingze Wang
Apr 12, 2007·Cancer Science·Akio OoyamaMasakazu Fukushima
Nov 28, 2014·Molecular Biology of the Cell·Jingyan LuoNu Zhang
Sep 17, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ning ZhangWei-Shan Chen
Nov 28, 2017·Scientific Reports·Dongya ZhangYayi Hou
Jun 22, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Pijus K SasmalAkhil R Chakravarty
Dec 28, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Sovan RoyAkhil R Chakravarty
Oct 7, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Basudev MaityAkhil R Chakravarty
Apr 5, 2014·Molecular Medicine Reports·Wei LiXuemin Wang
Jun 1, 2017·Molecular Medicine Reports·Xiao HeWei Yue
Feb 6, 2013·Oncology Reports·Se-Jung LeeSung-Kwon Moon
Mar 10, 2020·ACS Omega·Utso BhattacharyyaAkhil R Chakravarty
Sep 2, 2009·Inorganic Chemistry·Sovan RoyAkhil R Chakravarty
Mar 10, 2009·Inorganic Chemistry·Sounik SahaAkhil R Chakravarty
May 3, 2021·European Journal of Medicinal Chemistry·Meizhu WangWen Zhou
Jul 18, 2021·Scientific Reports·Louisa SternTarik Ghadban
Sep 25, 2021·Cancer Cell International·Beiquan HuDonghua Zou