PMID: 3322129Jan 1, 1987Paper

Regulation of megakaryocytopoiesis by thrombopoietin

Annals of the New York Academy of Sciences
T P McDonald

Abstract

It is clear that thrombopoietin is a major hormonal regulator of megakaryocytopoiesis both in vitro and in vivo, and, thus, blood platelet production. Existing data show that the action, chemical nature, and immunologic properties of thrombopoietin from HEK cell culture medium and either endogenously produced or exogenously administered thrombopoietin from animal sources are similar, if not identical. Absolute identity, however, will require comparisons of amino acid sequences of the two preparations. Recent studies have shown that not only does TSF potentiate the action of meg-CSF, but it also has a direct effect on precursor cells to increase the number of megakaryocytic colonies. Other in vitro work showed that TSF stimulates directly the SAChE+ precursor cells to become mature megakaryocytes and causes FMLC to differentiate into megakaryocytic colonies. In vivo, TSF increases megakaryocyte size and number, it causes an elevation in the number of the SAChE+ precursor cells in mouse marrow and increases the maturation of megakaryocytes. Moreover, TSF increases the endomitosis of megakaryocytes in the marrow of mice, along with elevating the number of megakaryocytic colonies in spleens of lethally irradiated bone marrow recons...Continue Reading

References

Sep 1, 1979·Intensive Care Medicine·J Kerr
Sep 1, 1978·Proceedings of the Society for Experimental Biology and Medicine·T P McDonald
May 22, 1978·Life Sciences·T P McDonaldG H Barlow
Feb 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·T T OdellR Clift
Feb 1, 1977·Scandinavian Journal of Haematology·T P McDonaldO Walasek
Jun 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·T T Odell, D A Boran
Jun 1, 1975·Biochemical Medicine·T P McDonald
Mar 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·A Nakeff, S Daniels-McQueen
Jun 1, 1987·Biochemical Medicine and Metabolic Biology·T P McDonaldM D Long
Jun 1, 1986·Proceedings of the Society for Experimental Biology and Medicine·T P McDonaldM Cottrell
Apr 1, 1986·Biochemical Society Transactions·M H Lewis
Apr 1, 1985·The Journal of Clinical Investigation·R HoffmanJ E Straneva
Oct 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·G D Kalmaz, T P McDonald
Nov 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·T P McDonald
Dec 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·T P McDonald
Mar 7, 1970·British Medical Journal·D G Penington
Mar 1, 1968·The Journal of Clinical Investigation·L A Harker
Sep 1, 1969·The Journal of Clinical Investigation·B L Evatt, J Levin
Mar 1, 1967·British Journal of Haematology·G De Gabriele, D G Penington
May 1, 1980·Journal of Cellular Physiology·S A BursteinL A Harker
Nov 1, 1984·British Journal of Haematology·D A LeporeD G Penington
Oct 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·T P McDonald, G D Kalmaz
Mar 1, 1983·Archives of Neurology·S O DellT Peterson
Dec 1, 1981·British Journal of Haematology·T P McDonald
Jun 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·G D Kalmaz, T P McDonald
Jan 1, 1981·Cell and Tissue Kinetics·M H FreedmanE F Saunders
Nov 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·T T ODELLT C DETWILER

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Citations

Oct 1, 1991·British Journal of Haematology·C W HollenS A Burstein
Sep 1, 1992·Journal of Veterinary Internal Medicine·D A O'Keefe, D J Schaeffer
Oct 1, 1992·Leukemia & Lymphoma·C W HollenS A Burstein
May 1, 1989·International Journal of Cell Cloning·T P McDonald
Mar 1, 1992·International Journal of Cell Cloning·H AvrahamJ E Groopman

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