Regulation of Meiotic Prophase One in Mammalian Oocytes.

Frontiers in Cell and Developmental Biology
Xiaoyi Wang, Melissa E Pepling

Abstract

In female mammals, meiotic prophase one begins during fetal development. Oocytes transition through the prophase one substages consisting of leptotene, zygotene, and pachytene, and are finally arrested at the diplotene substage, for months in mice and years in humans. After puberty, luteinizing hormone induces ovulation and meiotic resumption in a cohort of oocytes, driving the progression from meiotic prophase one to metaphase two. If fertilization occurs, the oocyte completes meiosis two followed by fusion with the sperm nucleus and preparation for zygotic divisions; otherwise, it is passed into the uterus and degenerates. Specifically in the mouse, oocytes enter meiosis at 13.5 days post coitum. As meiotic prophase one proceeds, chromosomes find their homologous partner, synapse, exchange genetic material between homologs and then begin to separate, remaining connected at recombination sites. At postnatal day 5, most of the oocytes have reached the late diplotene (or dictyate) substage of prophase one where they remain arrested until ovulation. This review focuses on events and mechanisms controlling the progression through meiotic prophase one, which include recombination, synapsis and control by signaling pathways. These e...Continue Reading

References

Jun 17, 1999·Trends in Cell Biology·M E PeplingA C Spradling
Apr 27, 2000·Endocrine Reviews·E A McGee, A J Hsueh
Dec 7, 2000·Molecular Cell·P J Romanienko, R D Camerini-Otero
Apr 3, 2001·Nature Reviews. Genetics·T Hassold, P Hunt
Jun 9, 2001·Developmental Biology·M E Pepling, A C Spradling
Jan 11, 2002·Developmental Biology·K A MolyneauxC Wylie
Jul 2, 2002·Nature Genetics·Steven M LipkinPaula E Cohen
Sep 1, 1961·Experimental Cell Research·K BORUM
Oct 11, 2003·Developmental Biology·Douglas B MenkeDavid C Page
Dec 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Brian J LibbyJohn C Schimenti
Jul 6, 2004·Molecular Reproduction and Development·Monica Bullejos, Peter Koopman
Jan 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Monica Di GiacomoMaria Jasin
Apr 19, 2005·Nature Structural & Molecular Biology·Galina V PetukhovaR Daniel Camerini-Otero
Dec 3, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Meisha A Morelli, Paula E Cohen
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jana KoubovaDavid C Page
Apr 1, 2006·Science·Josephine BowlesPeter Koopman
Jan 16, 2007·PLoS Genetics·Martha SusiarjoPatricia A Hunt
Mar 7, 2007·The Journal of Cell Biology·Ewelina Bolcun-FilasHoward J Cooke
Apr 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Johannes SchmittManfred Alsheimer
Jul 10, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Chuck R GreenfeldJodi A Flaws
Aug 6, 2008·Annual Review of Genetics·Wilhelm Palm, Titia de Lange
Sep 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ericka L AndersonDavid C Page
Jan 14, 2009·Genetics·Adam S Wilkins, Robin Holliday
Jul 9, 2009·Molecular Human Reproduction·G M HartshorneF Ghafari
Oct 21, 2009·The Journal of Cell Biology·Caroline AdelfalkRolf Jessberger
Oct 27, 2009·Trends in Cell Biology·Romain Koszul, Nancy Kleckner
Feb 20, 2010·Nature Reviews. Genetics·Kenneth Paigen, Petko Petkov

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