PMID: 3557070Sep 1, 1986

Regulation of melanotropin release from the pars intermedia of the amphibian Xenopus laevis: evaluation of the involvement of serotonergic, cholinergic, or adrenergic receptor mechanisms

General and Comparative Endocrinology
B M Verburg-van KemenadeA P Van Overbeeke


Melanophore-stimulating hormone (MSH) release from the pars intermedia of the pituitary gland is probably regulated by multiple factors of hypothalamic origin. We have examined a number of potential regulatory factors for their effects on MSH release from the amphibian Xenopus laevis. Serotonin and acetylcholine have no effect on MSH release. Both adrenaline and noradrenaline inhibit release of MSH in a dose-dependent manner. Studies with specific receptor agonists and antagonists reveal that these neurotransmitters exert their in vitro effects primarily through a dopamine D-2 receptor, although an alpha-adrenergic receptor could not be excluded. We further conclude that the pars intermedia of X. laevis lacks a beta-adrenergic receptor for the regulation of MSH secretion from the pars intermedia. In mammals, this receptor activates the adenylate cyclase system. Our studies reveal that despite the lack of beta-adrenergic receptors, cyclic-AMP is likely an intracellular factor involved in the stimulation of MSH release.


May 1, 1975·General and Comparative Endocrinology·M E HadleyA Bower
Jun 1, 1966·General and Comparative Endocrinology·K Dierst-DaviesJ L Pechersky
Jan 1, 1981·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·G J MartensA P Van Overbeeke


Jan 1, 1987·Peptides·B M Verburg-van KemenadeS Saint-Pierre
Jan 1, 1987·Peptides·B M Verburg-van KemenadeH Vaudry
Nov 1, 1986·Brain Research Bulletin·B M Verburg-van KemenadeA G Driessen
Jul 3, 2002·General and Comparative Endocrinology·E W RoubosB G Jenks
Dec 24, 1997·Comparative Biochemistry and Physiology. Part A, Physiology·E W Roubos
May 9, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·S M KolkE W Roubos
May 31, 1993·Annals of the New York Academy of Sciences·M C TononH Vaudry
Sep 25, 2010·Journal of Receptor and Signal Transduction Research·Tahira Sultan, Sharique A Ali
May 14, 2005·Annals of the New York Academy of Sciences·E W RoubosB G Jenks
Oct 1, 1989·General and Comparative Endocrinology·I D van ZoestB G Jenks
Jun 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·M LamaczH Vaudry
Aug 19, 2011·Journal of Receptor and Signal Transduction Research·Sharique A Ali, Keisham V Meitei
Dec 15, 2010·The European Journal of Neuroscience·E W RoubosB G Jenks
Apr 14, 1999·Journal of Neuroendocrinology·R UbinkE W Roubos

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Acetylcholine Sulfate (1: 1)
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