Regulation of Metabolic Activity by p53

Metabolites
Jessica FlöterAlmut Schulze

Abstract

Metabolic reprogramming in cancer cells is controlled by the activation of multiple oncogenic signalling pathways in order to promote macromolecule biosynthesis during rapid proliferation. Cancer cells also need to adapt their metabolism to survive and multiply under the metabolically compromised conditions provided by the tumour microenvironment. The tumour suppressor p53 interacts with the metabolic network at multiple nodes, mostly to reduce anabolic metabolism and promote preservation of cellular energy under conditions of nutrient restriction. Inactivation of this tumour suppressor by deletion or mutation is a frequent event in human cancer. While loss of p53 function lifts an important barrier to cancer development by deleting cell cycle and apoptosis checkpoints, it also removes a crucial regulatory mechanism and can render cancer cells highly sensitive to metabolic perturbation. In this review, we will summarise the major concepts of metabolic regulation by p53 and explore how this knowledge can be used to selectively target p53 deficient cancer cells in the context of the tumour microenvironment.

References

Mar 15, 1979·Nature·D P Lane, L V Crawford
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D EliyahuM Oren
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·P N FriedmanC Prives
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·K ForresterC C Harris
May 15, 1997·Nature·M H KubbutatK H Vousden
Sep 26, 1997·Nature·K PolyakB Vogelstein
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·K B WongA R Fersht
Jul 21, 2001·Molecular Cell·J YuB Vogelstein
Jul 21, 2001·Molecular Cell·K Nakano, K H Vousden
Mar 5, 2002·Nature Medicine·Vladimir J N BykovGalina Selivanova
Apr 26, 2003·Mutagenesis·Shaoyu ZhouKeshav K Singh
May 8, 2003·The Journal of Biological Chemistry·Naoya YahagiNobuhiro Yamada
Jan 6, 2004·Science·Lyubomir T VassilevEmily A Liu
Apr 3, 2004·Cancer Research·Fabiana Schwartzenberg-Bar-YosephEddy Karnieli
Nov 19, 2004·Nature·Scott W LoweGerard Evan
Apr 7, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Elena A KomarovaAndrei V Gudkov
May 4, 2005·Molecular Cell·Russell G JonesCraig B Thompson
May 26, 2005·The Journal of Biological Chemistry·Armando Rivera, Steve A Maxwell
Jun 14, 2005·Cancer Cell·Goberdhan P Dimri
Nov 16, 2005·Nature Medicine·Anna A SablinaPeter M Chumakov
Mar 18, 2006·Cell Death and Differentiation·J-C MarineG Lozano
May 27, 2006·Science·Satoaki MatobaPaul M Hwang
May 27, 2006·Cell Death and Differentiation·P StambolskyV Rotter
Jul 15, 2006·Cell·Karim BensaadKaren H Vousden
Dec 22, 2006·Cell·Carla P MartinsGerard I Evan
Jan 26, 2007·Nature·Andrea VenturaTyler Jacks
Feb 27, 2007·Oncogene·H F Horn, K H Vousden
Mar 24, 2007·Nature Reviews. Molecular Cell Biology·Karen H Vousden, David P Lane
Jun 7, 2007·Journal of Bioenergetics and Biomembranes·Wenzhe MaPaul M Hwang

❮ Previous
Next ❯

Citations

Mar 21, 2018·International Journal of Molecular Sciences·Jelena KrsticAndreas Prokesch
Aug 10, 2017·Metabolites·Madhu Basetti
Nov 28, 2017·Frontiers in Endocrinology·Pierre-Damien DenechaudAlbert Giralt
Sep 21, 2018·Frontiers in Oncology·Ramon BartronsUbaldo E Martinez-Outschoorn
Feb 16, 2019·British Journal of Cancer·Catia GiovanniniLaura Gramantieri
Jan 24, 2019·Oxidative Medicine and Cellular Longevity·Su Yeon LeeHo Sung Kang
Oct 23, 2019·International Journal of Molecular Sciences·Eunjung KimJoo-Yong Lee
May 10, 2018·Frontiers in Oncology·Maria Chiara De SantisAndrea Morandi
Jan 13, 2018·FEBS Letters·Jiajun HuangWenzhe Ma
Oct 19, 2019·Cancers·Sara LoponteAndrea Viale
Jun 1, 2018·Cancer Reports·Abdallah K AlameddineKhaled O Alameddine
Aug 15, 2020·Frontiers in Cell and Developmental Biology·Xiangyu SunYingying Xu
Oct 2, 2020·Cancers·Atsushi Tanabe, Hiroeki Sahara
Oct 30, 2020·Antioxidants & Redox Signaling·Huan-Ling LaiElaine Lai-Han Leung
Jun 2, 2020·Cytokine & Growth Factor Reviews·Katarzyna Dominika SluzalskaMalgorzata Zakrzewska
Mar 17, 2020·Chemico-biological Interactions·Keri A BarronNatalia I Krupenko
Jul 28, 2020·Advanced Drug Delivery Reviews·Lisa M ButlerJohannes V Swinnen
Jul 3, 2021·International Journal of Molecular Sciences·Miljana NenkovYuan Chen
Aug 10, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Payel MondalChandrima Das

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation
ubiquitination

Related Concepts

Related Feeds

Cancer Metabolic Reprogramming

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cancer Metabolic Reprogramming (Keystone)

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Related Papers

Biochemical and Biophysical Research Communications
Ewa MichalakAndreas Strasser
Critical Reviews in Eukaryotic Gene Expression
Xueli Fan, Jason J Chen
International Journal of Molecular Sciences
Alejandro Parrales, Tomoo Iwakuma
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
M Nakanishi
Chemical Research in Toxicology
Z A Stewart, J A Pietenpol
© 2022 Meta ULC. All rights reserved