PMID: 9178614Jun 1, 1997Paper

Regulation of metabolite flux through voltage-gating of VDAC channels

The Journal of Membrane Biology
T Hodge, M Colombini

Abstract

The mitochondrial outer membrane channel, VDAC, is thought to serve as the major permeability pathway for metabolite flux between the cytoplasm and mitochondria. The permeability of VDAC to citrate, succinate, and phosphate was studied in channels reconstituted into planar phospholipid membranes. All ions showed large changes in permeability depending on whether the channel was in the open or in the low conductance, "closed" state, with the closed state always more cation selective. This was especially true for the divalent and trivalent anions. Additionally, the anion flux when the voltage was zero was shown to decrease to 5-11% of the open state flux depending on the anion studied. These results give the first rigorous examination of the ability of metabolites to permeate through VDAC channels and indicate that these channels can control the flux of these ions through the outer membrane. This lends more evidence to the growing body of experiments that suggest that the outer mitochondrial membrane has a much more important role in controlling mitochondrial activity than has been thought historically.

Citations

Aug 16, 2008·Experimental Brain Research·Antonio FrigeriDavid C Spray
Oct 6, 2006·European Biophysics Journal : EBJ·Victor V Lemeshko
Apr 10, 2013·Apoptosis : an International Journal on Programmed Cell Death·Yoshihiro Takahashi, Chika Tateda
Jul 26, 2008·Journal of Bioenergetics and Biomembranes·Tatiana K Rostovtseva, Sergey M Bezrukov
Apr 27, 2013·Journal of Bioenergetics and Biomembranes·Daniela MeleleoGabriella Notarachille
Dec 26, 2001·Biophysical Journal·Tatiana K RostovtsevaMarco Colombini
Jan 20, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Johnathan C LaiCy A Stein
Apr 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Salah Abu-HamadVarda Shoshan-Barmatz
Feb 29, 2000·The Journal of General Physiology·L K Kaczmarek
Apr 29, 1998·Annual Review of Physiology·K Kirk, K Strange
Sep 30, 2006·Annual Review of Physiology·Elizabeth Murphy, Charles Steenbergen
Dec 17, 2010·Cancer Research·Eduardo N MaldonadoJohn J Lemasters
Oct 31, 2012·PloS One·Barbara MertinsLars-Oliver Essen
May 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Johnathan C LaiC A Stein
Sep 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jianxin Sun, James K Liao
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·M G Vander HeidenC B Thompson
Apr 10, 2014·Cell and Tissue Research·Michael K E SchäferAxel Methner
Apr 20, 2014·Mitochondrion·Eva-Maria KrammerFabrice Homblé
Dec 3, 2014·Biochimica Et Biophysica Acta·Debanjan TewariAmal Kanti Bera
Mar 9, 2013·The Journal of Biological Chemistry·Eduardo N MaldonadoJohn J Lemasters
Jul 5, 2011·FEBS Letters·Philip A GurnevSergey M Bezrukov
Feb 27, 2010·FEBS Letters·Vito De PintoAlfons Lawen
Jan 31, 2016·Biochimica Et Biophysica Acta·Marco Colombini
Nov 26, 2015·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Daniela Meleleo, Vittorio Picciarelli
Nov 18, 2000·The Journal of Physiology·B O'Rourke
Feb 3, 2009·FEBS Letters·Beth M McDonaldJeremy H Lakey
Dec 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Sarah A HeadJun O Liu
Oct 16, 2012·Fertility and Sterility·Woo-Sung KwonMyung-Geol Pang
Mar 25, 2011·Blood Cells, Molecules & Diseases·Serge L Y ThomasCéline Ollivaux
Jun 15, 2010·Biochemical and Biophysical Research Communications·Bianjiang LiuZengjun Wang

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