Regulation of MHC Class II-Peptide Complex Expression by Ubiquitination

Frontiers in Immunology
Kyung-Jin Cho, Paul A Roche

Abstract

MHC class II (MHC-II) molecules are present on antigen presenting cells (APCs) and these molecules function by binding antigenic peptides and presenting these peptides to antigen-specific CD4(+) T cells. APCs continuously generate and degrade MHC-II molecules, and ubiquitination of MHC-II has recently been shown to be a key regulator of MHC-II expression in dendritic cells (DCs). In this mini-review we will examine the mechanism by which the E3 ubiquitin ligase March-I regulates MHC-II expression on APCs and will discuss the functional consequences of altering MHC-II ubiquitination.

References

May 15, 2015·Journal of Immunological Methods·Cassandra M HenniesEdith M Janssen
Jan 13, 2015·Current Opinion in Immunology·Justine D MinternJose A Villadangos
Apr 4, 2017·Médecine sciences : M/S·Sylviane Muller
Jun 12, 2019·International Journal of Immunogenetics·B Sean CareyAnthony Poles

Related Concepts

T-Lymphocyte
Antigen-Presenting Cells
Genes, MHC Class II
Antigens
APCS gene
MARCH1 gene
Ubiquitin-protein ligase
Dendritic Cells
Atrial Premature Complexes
Ubiquitination

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