Regulation of microtubule (MT)-based cytoskeleton in the seminiferous epithelium during spermatogenesis

Seminars in Cell & Developmental Biology
Elizabeth I TangC Yan Cheng

Abstract

In rodents and humans, testicular cells, similar to other mammalian cells, are supported by actin-, microtubule (MT)- and intermediate filament-based cytoskeletons. Although the cytoskeletal network of the testis serves an important role in regulating spermatogenesis during the epithelial cycle, most of the published findings in the literature are limited to studies that only visualize these cytoskeletons in the seminiferous epithelium. Few focus on the underlying molecular mechanism that regulates their organization in the epithelium in response to changes in the stages of the epithelial cycle. Functional studies in the last decade have begun to focus on the role of binding proteins that regulate these cytoskeletons, with some interesting findings rapidly emerging in the field. Since the actin- and intermediate filament-based cytoskeletons have been recently reviewed, herein we focus on the MT-based cytoskeleton for two reasons. First, besides serving as a structural support cytoskeleton, MTs are known to serve as the track to support and facilitate the transport of germ cells, such as preleptotene spermatocytes connected in clones and elongating/elongated spermatids during spermiogenesis, across the blood-testis barrier (BTB)...Continue Reading

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Citations

Apr 26, 2016·Seminars in Cell & Developmental Biology·Haiqi Chen, C Yan Cheng
Jan 27, 2017·Critical Reviews in Biochemistry and Molecular Biology·Tito T JesusMarco G Alves
Jul 18, 2018·American Journal of Physiology. Endocrinology and Metabolism·Qing WenC Yan Cheng
Sep 21, 2017·F1000Research·Linxi LiC Yan Cheng
Feb 13, 2018·Cell Death & Disease·Qing WenC Yan Cheng
May 22, 2019·American Journal of Physiology. Endocrinology and Metabolism·Ming YanC Yan Cheng
Aug 10, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Bai-Ping MaoC Yan Cheng
Nov 7, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ying GaoC Yan Cheng
Jul 11, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lingling WangC Yan Cheng
Oct 24, 2018·The World Journal of Men's Health·Sezgin GunesAshok Agarwal
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shiwen LiuC Yan Cheng
Feb 8, 2018·Seminars in Cell & Developmental Biology·Linxi LiC Yan Cheng
Sep 20, 2017·Seminars in Cell & Developmental Biology·Haiqi ChenC Yan Cheng
Jun 6, 2021·Toxicology and Applied Pharmacology·A S VallésN E Furland
Sep 28, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Siwen WuC Yan Cheng
Nov 4, 2021·Cell Reports·Haiqi ChenFei Chen

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