Regulation of Microvascular Function by Adipose Tissue in Obesity and Type 2 Diabetes: Evidence of an Adipose-Vascular Loop.

American Journal of Biomedical Sciences
Hanrui Zhang, Cuihua Zhang

Abstract

In recent years, the general concept has emerged that chronic low-grade inflammation is the condition linking excessive development of adipose tissue and obesity-associated pathologies such as type 2 diabetes and cardiovascular diseases. Obesity and type 2 diabetes are characterized by a diminished production of protective factors such as adiponectin and increased detrimental adipocytokines such as leptin, resistin, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNFα), and monocyte chemoattractant protein-1 (MCP-1) by adipose tissue. Moreover, the evidence that the growth of the fat mass is associated with an accumulation of adipose tissue macrophages and T-lymphocytes has raised the hypothesis that the development of an inflammatory process within the growing fat mass is a primary event involved in the genesis of systemic metabolic and vascular alterations. This crosstalk of adipocyte, macrophage, lymphocyte, endothelial cells, and vascular smooth muscle cells contribute to the production of various cytokines, chemokines, and hormone-like factors, which actively participate in the regulation of vascular function by an endocrine and/or paracrine pattern. Thus, the signaling from perivascular adipose to the blood vessels is ...Continue Reading

Citations

May 13, 2010·Pediatric Cardiology·Osman OzdemirSinef Aksoy
Dec 23, 2011·Basic Research in Cardiology·Hanrui ZhangCuihua Zhang
Jun 21, 2011·Clinical Lipidology·Kathryn A Britton, Caroline S Fox
Oct 1, 2013·Atherosclerosis·Hae-Young LeeKwang Kon Koh
Mar 8, 2018·Current Hypertension Reports·Sergey KachurCarl J Lavie
Dec 24, 2010·World Journal of Cardiology·Hanrui ZhangCuihua Zhang
Mar 20, 2012·Circulation Research·Kirsti A CampbellColeen A McNamara
Sep 14, 2011·Clinical Science·Theodora Szasz, R Clinton Webb
Feb 5, 2014·British Journal of Pharmacology·T A M AlmabroukS Kennedy
Apr 27, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Zoltan UngvariAnna Csiszar
May 6, 2011·Diabetes Care·Patricia Iozzo
Mar 24, 2011·British Journal of Pharmacology·Satomi KagotaJohn J McGuire
Feb 6, 2016·Journal of Cardiovascular Pharmacology·Aishah Al-Jarallah, Mabayoje A Oriowo
Oct 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Elizabeth E Ha, Robert C Bauer
May 7, 2011·British Journal of Pharmacology·Gregory A PayneJohnathan D Tune
Mar 17, 2015·Journal of Endocrinological Investigation·K Selthofer-Relatić, I Bošnjak
Jan 30, 2021·Biofabrication·Hannah A StrobelJames B Hoying
Apr 2, 2020·American Journal of Perinatology·Kathleen M AntonyKjersti M Aagaard

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