Regulation of microvascularization in heart failure - an endothelial cell, non-coding RNAs and exosome liaison

Non-coding RNA Research
Rio P JuniPaula A da Costa Martins

Abstract

Heart failure is a complex syndrome involving various pathophysiological processes. An increasing body of evidence shows that the myocardial microvasculature is essential for the homeostasis state and that a decompensated heart is associated with microvascular dysfunction as a result of impaired endothelial angiogenic capacity. The intercellular communication between endothelial cells and cardiomyocytes through various signaling molecules, such as vascular endothelial growth factor, nitric oxide, and non-coding RNAs is an important determinant of cardiac microvascular function. Non-coding RNAs are transported from endothelial cells to cardiomyocytes, and vice versa, regulating microvascular properties and angiogenic processes in the heart. Small-exocytosed vesicles, called exosomes, which are secreted by both cell types, can mediate this intercellular communication. The purpose of this review is to highlight the contribution of the microvasculature to proper heart function maintenance by focusing on the interaction between cardiac endothelial cells and myocytes with a specific emphasis on non-coding RNAs (ncRNAs) in this form of cell-to-cell communication. Finally, the potential of ncRNAs as targets for angiogenesis therapy wil...Continue Reading

Citations

Dec 12, 2018·Journal of Cellular Physiology·Farzaneh GhafarianAmir Avan
Mar 28, 2019·Vascular Biology·Ebba Brakenhielm, Vincent Richard
Dec 10, 2020·International Journal of Molecular Sciences·Abdul Q KhanShahab Uddin
Feb 12, 2021·Nature Reviews. Cardiology·Begoña LópezJavier Díez
Jul 31, 2019·Biochimica Et Biophysica Acta. Molecular Cell Research·Marijn M C PetersPaula A da Costa Martins

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BETA
transfection

Software Mentioned

AGENT
KAT
VIVA

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