PMID: 11903625Mar 21, 2002Paper

Regulation of midgut defensin production in the blood-sucking insect Stomoxys calcitrans

Insect Molecular Biology
R J L MunksM J Lehane

Abstract

The Stomoxys midgut defensin (Smd) family of genes are exclusively expressed in the anterior midgut of adult flies. Their putative function is protection of the stored bloodmeal from microbial attack. Smd genes are constitutively expressed, up-regulated in response to a bloodmeal and further up-regulated by immune stimulation per os but only in the presence of a bloodmeal not a sugar meal. Smd genes are down-regulated in response to a systemic immune challenge. Smd gene constructs transfected into l(2)mbn cells undertake constitutive expression but are not up-regulated by immune challenge. Electrophoretic mobility shift assays (EMSA) suggest the rel-like sites in the proximal promoter region of Smd genes do not bind midgut factors and so are non-functional.

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Citations

Oct 18, 2003·Insect Biochemistry and Molecular Biology·Zhengrong HaoSerap Aksoy
Dec 3, 2003·Trends in Genetics : TIG·Oren Froy, Michael Gurevitz
Oct 18, 2003·Insect Biochemistry and Molecular Biology·Shane M CeraulWayne L Hynes
Jun 12, 2012·Journal of Medical Entomology·Kristina M Friesen, Gregory D Johnson
Oct 4, 2014·Journal of Medical Entomology·Pia Untalan OlafsonGuy H Loneragan
Jul 22, 2005·Insect Molecular Biology·L Viljakainen, P Pamilo
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May 5, 2004·Best Practice & Research. Clinical Gastroenterology·Andre J Ouellette
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Oct 9, 2015·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Ana Paula Rodrigues de MoraesAvelino José Bittencourt
Oct 4, 2003·The Journal of Biological Chemistry·Cécile ThouzeauPhilippe Bulet

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