Regulation of milk lipid formation and secretion in the mouse mammary gland

Advances in Experimental Medicine and Biology
James L McManamanMargaret C Neville

Abstract

Cytosolic lipid droplets (CLDs), the immediate precursors of milk lipids in lactating animals, undergo cell-specific changes in their formation and intracellular distribution during mammary gland differentiation. Cell biological studies indicate that CLD formation in mammary epithelial cells is regulated in part by AKT-dependent increases in glucose uptake. Proteomic studies show that CLDs from lactating mammary epithelial cells possess a distinct protein composition enriched in molecules involved in their secretion and intracellular transport. CLD secretion is dependent on lactation and requires the purine catabolic enzyme xanthine oxidoreductase (XOR). Confocal immunofluorescence microscopy of XOR in lactating and nonlactating mammary glands and biochemical analysis of secreted CLDs link the secretion process to the formation of a stable tripartite complex between XOR, adipophilin (ADPH), and butyrophilin (Btn). Together these studies provide a molecular and cellular framework for understanding the process of milk lipid formation.

Citations

Jan 27, 2005·American Journal of Physiology. Endocrinology and Metabolism·David J FlintPaul A Kelly
Nov 23, 2013·Journal of Mammary Gland Biology and Neoplasia·Sandrine TruchetMichèle Ollivier-Bousquet
Nov 6, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nicholas H McCormickShannon L Kelleher
Apr 24, 2019·Asian-Australasian Journal of Animal Sciences·Subi SugathanNaresh Kumar Singh
Nov 14, 2007·Journal of Mammary Gland Biology and Neoplasia·James L McManamanHorst Robenek
Dec 1, 2006·Journal of Mammary Gland Biology and Neoplasia·James L McManamanEdwin C Thrower
Dec 25, 2008·Functional & Integrative Genomics·Karensa K MenziesKevin R Nicholas
Jul 27, 2011·PloS One·Andreas F KolbC Bruce A Whitelaw
Feb 26, 2014·Journal of Mammary Gland Biology and Neoplasia·James L McManaman
Nov 11, 2010·Journal of Cell Communication and Signaling·Bethanie Morrison, Mary Lou Cutler
Feb 9, 2018·PLoS Genetics·Rui ZhangGaoxiang Ge
Dec 22, 2015·Cancer Medicine·Maria Giulia BattelliAndrea Bolognesi
Mar 9, 2011·The Journal of Biological Chemistry·Brandi M ChongJames L McManaman
Jan 25, 2008·BMC Developmental Biology·Harriet WatkinSteven M Anderson
Jun 3, 2014·Biochimica Et Biophysica Acta·Maria Giulia BattelliLetizia Polito

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